CBX8 Suppresses Tumor Metastasis via Repressing Snail in Esophageal Squamous Cell Carcinoma.
CBX8 Suppresses Tumor Metastasis via Repressing Snail in Esophageal Squamous Cell Carcinoma.
复制标题
CBX8 通过抑制食管鳞状细胞癌中的 Snail 来抑制肿瘤转移
作者：
Wang G;Tang J;Zhan W;Zhang R;Zhang M;Liao D;Wang X;Wu Y;Kang T
食管鳞状细胞癌(ESCC)的高侵袭性和高转移性是其临床转归和预后差的主要原因，迫切需要进一步探讨ESCC转移的分子机制。每个多梳染色框(CBX)蛋白在癌症中的功能与细胞类型有关。虽然CBX8已被报道促进食管鳞癌的发生，但其在食管鳞癌转移中的作用尚未得到研究。在这项研究中，我们报道了在ESCC中抑制细胞的迁移、侵袭和转移需要CBX8介导的对Snail的抑制，Snail是诱导上皮向间充质转化(EMT)的关键转录因子，并且CBX8与ESCC组织中的Snail呈负相关。此外，CBX8的这一新功能依赖于它与Snail启动子的结合，而Snail启动子反过来又抑制Snail的转录。总体而言，CBX8可能在ESCC中扮演矛盾的角色，在抑制转移的同时促进细胞增殖。
The poor clinical outcome and prognosis of esophageal squamous cell carcinoma (ESCC) is mainly attributed to its highly invasive and metastatic nature, making it urgent to further elicit the molecular mechanisms of the metastasis of ESCC. The function of each polycomb chromobox (CBX) protein in cancer is cell-type-dependent. Although CBX8 has been reported to promote the esophageal squamous cell carcinoma (ESCC) tumorigenesis, its role in ESCC metastasis has not been explored yet. In this study, we report that the inhibition of cell migration, invasion, and metastasis in ESCC requires CBX8-mediated repression of Snail, a key transcription factor that induces epithelial-to-mesenchymal transition (EMT), and that CBX8 inversely correlated with Snail in the ESCC tissues. Moreover, this novel function of CBX8 is dependent on its binding with the Snail promoter, which in turn suppresses the transcription of Snail. Collectively, CBX8 may play paradoxical roles in ESCC, inhibiting metastasis while promoting cell proliferation.