Relationship between homocysteine and neopterin concentrations in patients with gynecological cancer.
Relationship between homocysteine and neopterin concentrations in patients with gynecological cancer.
复制标题
妇科癌症患者同型半胱氨酸与新蝶呤浓度的关系。
DOI：
10.1016/j.canlet.2005.09.009
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发表时间：
2006
期刊：
影响因子：
9.7
通讯作者：
D. Fuchs
中科院分区：
文献类型：
--
作者：
K. Schroecksnadel;B. Frick;C. Winkler;L. Fuith;D. Fuchs
高浓度的血管危险因子同型半胱氨酸已被描述在恶性疾病患者中，并且同型半胱氨酸被认为是有用的肿瘤标志物。同样，在患有癌症的患者中经常观察到Th 1型免疫活化标记物新蝶呤浓度升高，并用作患者存活的预后标记物。在这项研究中，同型半胱氨酸和新蝶呤浓度之间的关系进行了研究，在18例妇科癌症。采用高效液相色谱法测定患者血清同型半胱氨酸和半胱氨酸浓度，放射免疫法测定叶酸和维生素B12水平，酶联免疫吸附法测定新蝶呤浓度。中位同型半胱氨酸浓度为11.2μM（四分位距：9.9-13.2μM），3例患者的水平高于15μM（正常范围的上限）。13名患者的新蝶呤浓度升高（中位数：11.6; 7.7- 24.9 nM），半胱氨酸（中位数：234; 216-255μM）、叶酸（中位数：7.8; 6.2- 11.7 ng/ml）和维生素B12（中位数：352; 258- 570 pg/ml）浓度均在参考范围内，但处于较低水平。高同型半胱氨酸浓度与低叶酸浓度呈负相关（rs=-0.605; P<0.01），并且在半胱氨酸水平较高的患者中倾向于更高（rs=0.457; P<0.06;）。同型半胱氨酸与免疫活化标志物新喋呤之间无相关性，但同型半胱氨酸浓度升高的3例患者的新喋呤水平也有升高的趋势（P<0.07）。结论：只有少数妇科恶性肿瘤患者存在同型半胱氨酸浓度升高，高同型半胱氨酸血症与免疫激活现象的相关性较弱，肿瘤细胞增殖可能是同型半胱氨酸升高的重要原因。
Elevated concentrations of vascular risk factor homocysteine have been described in patients with malignant diseases, and homocysteine was supposed to be useful as tumor marker. Likewise, elevated concentrations of Th1-type immune activation marker neopterin are frequently observed in patients suffering from cancer and serve as prognostic marker for the survival of patients. In this study, the relationship between homocysteine and neopterin concentrations was examined in 18 patients with gynecological cancer. Concentrations of homocysteine and cysteine were measured by HPLC in sera of patients, folic acid and vitamin B12levels were determined by radioimmunoassay, and neopterin concentrations were measured by ELISA. Median homocysteine concentration was 11.2μM (interquartile range: 9.9–13.2μM), 3 patients had levels higher than 15μM, the upper limit of the normal range. Neopterin concentrations were increased in 13 patients (median: 11.6; 7.7–24.9nM), cysteine (median: 234; 216–255μM), folate (median: 7.8; 6.2–11.7ng/ml) and vitamin B12(median: 352; 258–570pg/ml) concentrations were all within reference ranges although rather at the lower side. Higher homocysteine concentrations correlated inversely with low folate concentrations (rs=−0.605; P<0.01) and tended to be higher in patients with higher cysteine levels (rs=0.457; P<0.06; ). No correlation was found between homocysteine and immune activation marker neopterin, although the three patients with elevated homocysteine concentrations tended to have higher neopterin levels as well (P<0.07). In conclusion, only a few patients with gynecological cancer present with elevated homocysteine concentrations and hyperhomocysteinemia seems only weakly related to immune activation phenomena, tumor cell proliferation probably is more important for the increase of homocysteine.
DOI：
10.1093/jnci/95.5.373
发表时间：
2003-03-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Zhang, SM;Willett, WC;Hankinson, SE
通讯作者：
Hankinson, SE