Calcium regulation of Drosophila development.
Calcium regulation of Drosophila development.
复制标题
果蝇发育的钙调节。
DOI：
10.1016/s1040-7952(05)80015-1
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Beckingham,K
中科院分区：
文献类型：
--
作者：
Beckingham,K
More than half a century of intense genetic analysis has made Drosophila the multi-cellular organism of choice for studies of gene function in vivo. A by-product of the high level of genetic understanding has been the development of sophisticated molecular/genetic tools that make reintroduction of genes into the genome and cloning of genes identified by mutant phenotypes or unusual expression patterns relatively routine experimental procedures. In addition, methods that will allow substitution of reintroduced, mutated genes for their wild-type chromosomal counterparts have recently been developed (1). The cumulative effect of these various methodologies has been the generation of a system for the study of gene action that is of unpar-alleled power and scope.To date, however, the central focus for research in Drosophila has been the identification of key regulatory genes that control pattern formation in development, particularly during embryogenesis. Many of the key genes identified have proved to encode transcription factors and thus the emphasis in the more detailed biochemical work that has followed has been on DNA binding-related activities that is, areas
