A longitudinal MRI study in children with Rasmussen syndrome
A longitudinal MRI study in children with Rasmussen syndrome
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DOI：
10.1016/s0887-8994(02)00437-x
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发表时间：
2002-10-01
影响因子：
3.8
通讯作者：
Smith, JR
中科院分区：
文献类型：
--
作者：
Kim, SJ;Park, YD;Smith, JR
本研究的目的是使用磁共振成像（MRI）确定Rasmussen综合征的任何神经影像学模式的存在。这是一项前瞻性研究，评估了7例经神经病理学证实的Rasmussen综合征患儿的脑MRI。所有患者均对常规抗癫痫药无反应; 5例患者随后接受功能性大脑半球切除术，2例患者接受皮质切除术。每例患者进行三至八次（平均= 4.7）MRI，并进行脑神经病理学检查。连续性部分性癫痫发作前12个月和发作后9个月之间获得系列MRI。最初MRI信号改变的最常见区域是额中央区（6例患者）。观察到以下三种神经影像学异常模式：（1）MRI正常，随后信号强度增加，随时间推移出现进行性皮质萎缩;（2）最初局灶性信号强度增加，随后信号强度的空间范围和程度降低;（3）最初信号强度增加，随访扫描时无进一步变化。这一观察结果表明，Rasmussen综合征患者的MRI改变可能有三种不同的模式，这些神经影像学模式的差异可能反映了Rasmussen综合征发病机制的内在差异。(C)2002年，Elsevier Science Inc. All rights reserved.
The aim of this study was to identify the presence of any neuroimaging patterns of Rasmussen syndrome using magnetic resonance imaging (MRI). This was a prospective study evaluating brain MRIs in seven children with neuropathologically proven Rasmussen syndrome. All patients were unresponsive to conventional antiepileptics; five patients subsequently underwent functional hemispherectomy, and two patients underwent cortical resection. Three to eight (mean = 4.7) MRIs per patient were performed, and neuropathologic examination of the brain was available. Serial MRIs were obtained between 12 months before and 9 months after the onset of epilepsia partialis continua. The most common region of initial MRI signal change was the frontocentral region (six patients). Three patterns of neuroimaging abnormalities were observed as follows: (1) normal MRI followed by increased signal intensity with progressive cortical atrophy over time, (2) initial increased focal signal intensity followed by decrease in spatial extent and degree of signal intensity; (3) initially increased signal intensity without further changes on follow-up scans. This observation suggests three possible distinct patterns of MRI changes in patients with Rasmussen syndrome and that the differences in these neuroimaging patterns may reflect inherent differences in the pathogenesis of Rasmussen syndrome. (C) 2002 by Elsevier Science Inc. All rights reserved.