Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women
Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women
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DOI：
10.1002/jbmr.2979
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发表时间：
2017-02-01
影响因子：
6.2
通讯作者：
Stein, Emily M.
中科院分区：
文献类型：
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作者：
Carrelli, Angela;Bucovsky, Mariana;Stein, Emily M.
虽然维生素D缺乏症在肥胖人群中普遍存在，但其原因尚不清楚。很少有研究测量肥胖（OB）受试者脂肪中的维生素D浓度，并且没有一项研究包括正常体重对照（C）。本研究的目的是调查OB和C之间的身体组成、血清25-羟基维生素D（25 OHD）、皮下（SQ）和网膜（OM）脂肪中的维生素D以及维生素D的总脂肪储存量之间的关系是否存在差异。接受减肥手术的肥胖女性和因良性妇科疾病接受腹部手术的正常体重女性入选。受试者通过高效液相色谱法（HPLC）测量血清25 OHD，通过双能X线吸收法（DXA）测量身体成分。用质谱法测定SQ和OM脂肪中维生素D的浓度。有36名妇女参加。两组之间的血清25 OHD相似（OB 27 +/- 2 vs C 26 +/- 2 ng/mL; p = 0.71）。SQ（OB 34 +/- 9 vs C 26 +/- 12 ng/g; p = 0.63）或OM隔室（OB 51 +/- 13 vs C 30 +/- 18 ng/g; p = 0.37）中的脂肪维生素D浓度无显著差异。维生素D在SQ和OM隔室之间的分布在组间相似。血清25 OHD与两组的脂肪维生素D直接相关。OB组的维生素D总储存量显著高于C组（分别为2.3 +/- 0.6和0.4 +/- 0.8 mg; p < 0.01）。总之，虽然OB的总维生素D储存量显著高于C，但血清25 OHD和脂肪维生素D之间的关系以及OM和SQ脂肪隔室之间维生素D分布的总体模式相似。我们的数据表明，肥胖受试者有更多的维生素D脂肪储存。他们支持这样的假设，即肥胖个体的脂肪量增加是维生素D的储存库，而使该储存库饱和所需的维生素D量增加可能使肥胖个体容易出现血清25 OHD不足。(C)2016年美国骨与矿物质研究学会。
Although vitamin D deficiency is prevalent among obese individuals, its cause is poorly understood. Few studies have measured vitamin D concentrations in adipose of obese (OB) subjects, and none have included normal weight controls (C). The goal of this study was to investigate whether the relationship between body composition, serum 25-hydroxyvitamin D (25OHD), vitamin D in subcutaneous (SQ) and omental (OM) adipose, and total adipose stores of vitamin D differ among OB and C. Obese women undergoing bariatric surgery and normal-weight women undergoing abdominal surgery for benign gynecologic conditions were enrolled. Subjects had measurements of serum 25OHD by high-performance liquid chromatography (HPLC) and body composition by dual-energy X-ray absorptiometry (DXA). Vitamin D concentrations in SQ and OM adipose were measured by mass spectroscopy. Thirty-six women were enrolled. Serum 25OHD was similar between groups (OB 27 +/- 2 versus C 26 +/- 2 ng/mL; p = 0.71). Adipose vitamin D concentrations were not significantly different in either SQ (OB 34 +/- 9 versus C 26 +/- 12 ng/g; p = 0.63) or OM compartments (OB 51 +/- 13 versus C 30 +/- 18 ng/g; p = 0.37). The distribution of vitamin D between SQ and OM compartments was similar between groups. Serum 25OHD was directly related to adipose vitamin D in both groups. Total body vitamin D stores were significantly greater in OB than in C (2.3 +/- 0.6 versus 0.4 +/- 0.8 mg, respectively; p < 0.01). In summary, although OB had significantly greater total vitamin D stores than C, the relationship between serum 25OHD and fat vitamin D and the overall pattern of distribution of vitamin D between the OM and SQ fat compartments was similar. Our data demonstrate that obese subjects have greater adipose stores of vitamin D. They support the hypotheses that the enlarged adipose mass in obese individuals serves as a reservoir for vitamin D and that the increased amount of vitamin D required to saturate this depot may predispose obese individuals to inadequate serum 25OHD. (C) 2016 American Society for Bone and Mineral Research.