The recovery of noradrenaline in adrenergic nerve terminals of the rat after reserpine treatment *
The recovery of noradrenaline in adrenergic nerve terminals of the rat after reserpine treatment *
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DOI：
10.1111/j.2042-7158.1971.tb08617.x
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发表时间：
1971-02
影响因子：
3.3
通讯作者：
J. Häggendal;A. Dahlström
中科院分区：
文献类型：
--
作者：
J. Häggendal;A. Dahlström
本文观察了大剂量利血平(10 mg/kg)对大鼠心脏、颌下腺和腓肠肌组织内源性去甲肾上腺素的影响。在最初耗尽胺后，浓度在24~36小时内开始上升，此后一周左右，胺恢复较快，然后恢复速度减慢。在第4周和第6周之间，三种组织中去甲肾上腺素的浓度都有明显的下降，明显从第4周开始，在利血平治疗的第5周下降幅度最大，约为20%。此后，利血平治疗约6周后，血药浓度升高至接近正常水平。这些结果与新形成的胺储存颗粒的轴突向下运输以及这些颗粒在神经末梢的寿命有关。去甲肾上腺素恢复曲线的不同部分似乎反映了颗粒的轴突向下流动。计算了基于颗粒传输的理论恢复曲线。这一曲线与观察到的恢复曲线相似。利血平治疗后肾上腺素能功能和去甲肾上腺素水平的恢复是由于新形成的胺储存颗粒向神经末梢下转运所致。似乎没有必要将储存功能在利血平阻断的陈旧颗粒中重新出现作为大剂量利血平后去甲肾上腺素恢复的一种机制。
Tissue concentrations of endogenous noradrenaline in heart, submaxillary gland, and gastrocnemic muscle have been examined after one large dose of reserpine (10 mg/kg) to rats. After the initial depletion of the amine, the concentration started to rise between 24 and 36 h. For about one week thereafter the amine recovery proceeded comparatively fast, then the rate of the recovery slowed. Between the 4th and the 6th weeks there was a pronounced drop in the noradrenaline concentration in all three tissues, apparently beginning in the 4th week with a maximal decrease of about 20% in the 5th week after reserpine. Thereafter the concentrations increased to approach normal about 6 weeks after reserpine. These results are discussed in relation to the axonal down‐transport of newly formed amine storage granules and to the life‐span of these granules in the nerve terminals. The different parts of the noradrenaline recovery curve appeared to reflect the axonal down‐flow of granules. A theoretical recovery curve was calculated, based on granular transport. This curve was similar to the observed recovery curve. The claim is made that the recovery of adrenergic function and noradrenaline levels after reserpine is due to a down‐transport of newly formed, amine storage granules to the nerve terminals. There seems little need for the theory that the storage function reappears in old, reserpine‐blocked granules, as a mechanism for noradrenaline recovery after a large dose of reserpine.