Going nuclear: gene family evolution and vertebrate phylogeny reconciled
Going nuclear: gene family evolution and vertebrate phylogeny reconciled
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DOI：
10.1098/rspb.2002.2074
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发表时间：
2002-08-07
影响因子：
4.7
通讯作者：
Page, RDM
中科院分区：
文献类型：
--
作者：
Cotton, JA;Page, RDM
基因复制在脊椎动物的进化过程中是很常见的，它引入了旁系关系，从而使从核基因进行遗传推断变得复杂。同源树是一种能够处理旁系关系的方法，利用基因同源性和含有这些基因的生物体的同源性之间的关系来识别基因复制事件。这使我们能够从含有直系同源和旁系同源拷贝的基因家族中推断出同源性。从形态学和古生物学数据中可以很好地理解脊椎动物的发生，但是使用线粒体序列数据的研究未能重现这一经典观点。对118个脊椎动物基因家族的数据库进行的聚类树分析支持了一个很大程度上经典的脊椎动物遗传学。
Gene duplications have been common throughout vertebrate evolution, introducing paralogy and so complicating phylogenctic inference from nuclear genes. Reconciled trees are one method capable of dealing with paralogy, using the relationship between a gene phylogeny and the phylogeny of the organisms containing those genes to identify gene duplication events. This allows us to infer phylogenies from gene families containing both orthologous and paralogous copies. Vertebrate phylogeny is well understood from morphological and palaeontological data, but studies using mitochondrial sequence data have failed to reproduce this classical view. Reconciled tree analysis of a database of 118 vertebrate gene families supports a largely classical vertebrate phylogeny.