Creatine kinase in ischemic and inflammatory disorders.
Creatine kinase in ischemic and inflammatory disorders.
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DOI：
10.1186/s40169-016-0114-5
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发表时间：
2016-12
影响因子：
10.6
通讯作者：
Glover LE
中科院分区：
文献类型：
--
作者：
Kitzenberg D;Colgan SP;Glover LE
肌酸/磷酸肌酸途径在能量代谢中起着保守且核心的作用。特定肌酸激酶的区室化允许以热力学有利的方式缓冲局部高能磷酸盐，从而实现细胞内的快速能量存储和能量转移。通过补充营养肌酸来增强这种代谢途径已被证明可以对许多不同的病理学产生有益的效果，特别是那些引起组织缺血、缺氧或氧化应激的病理学。在这些情况下，肌酸和磷酸肌酸可防止细胞内 ATP 的消耗和内部酸化，增强蛋白质合成的缺血后恢复并促进自由基清除和细胞膜的稳定。肌酸激酶能量系统本身受到缺氧信号的进一步调节，突显哺乳动物中存在内源性机制，可以在缺氧期间增强肌酸代谢，从而促进组织溶解和体内平衡。在这里，我们回顾了对肌酸激酶途径的最新见解，并为人类缺血和炎症病理中膳食肌酸补充剂提供了基本原理。
The creatine/phosphocreatine pathway plays a conserved and central role in energy metabolism. Compartmentalization of specific creatine kinase enzymes permits buffering of local high energy phosphates in a thermodynamically favorable manner, enabling both rapid energy storage and energy transfer within the cell. Augmentation of this metabolic pathway by nutritional creatine supplementation has been shown to elicit beneficial effects in a number of diverse pathologies, particularly those that incur tissue ischemia, hypoxia or oxidative stress. In these settings, creatine and phosphocreatine prevent depletion of intracellular ATP and internal acidification, enhance post-ischemic recovery of protein synthesis and promote free radical scavenging and stabilization of cellular membranes. The creatine kinase energy system is itself further regulated by hypoxic signaling, highlighting the existence of endogenous mechanisms in mammals that can enhance creatine metabolism during oxygen deprivation to promote tissue resolution and homeostasis. Here, we review recent insights into the creatine kinase pathway, and provide rationale for dietary creatine supplementation in human ischemic and inflammatory pathologies.