All the "RAGE" in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses.
All the "RAGE" in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses.
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DOI：
10.1016/j.prrv.2017.03.012
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发表时间：
2017-06
影响因子：
5.8
通讯作者：
Oury TD
中科院分区：
文献类型：
--
作者：
Oczypok EA;Perkins TN;Oury TD
晚期糖基化终产物受体（receptor for advanced glycation endproducts，PRR）是一种促炎性模式识别受体（pro-inflammatory pattern recognition receptor，PRR），参与多种炎症性疾病的发病机制。它于1992年在内皮细胞上被发现，并因其结合晚期糖基化终产物和促进糖尿病患者血管炎症的能力而命名。进一步的研究表明，β-淀粉样蛋白在肺组织中表达最高，并激发了对β-淀粉样蛋白在肺中作用的大量探索。这些研究已经发现，在过敏性气道炎症（AAI）和哮喘、肺纤维化、肺癌、慢性阻塞性肺病（COPD）、急性肺损伤、肺炎、囊性纤维化和支气管肺发育不良中，β-内酰胺酶是重要的介质。目前尚未在儿科或成人临床人群的肺部靶向治疗肺结核，但抑制肺结核的新方法的开发为患有这些肺部疾病的患者的新型治疗药物的出现奠定了基础。
The receptor for advanced glycation endproducts (RAGE) is a pro-inflammatory pattern recognition receptor (PRR) that has been implicated in the pathogenesis of numerous inflammatory diseases. It was discovered in 1992 on endothelial cells and was named for its ability to bind advanced glycation endproducts and promote vascular inflammation in the vessels of patients with diabetes. Further studies revealed that RAGE is most highly expressed in lung tissue and spurred numerous explorations into RAGE’s role in the lung. These studies have found that RAGE is an important mediator in allergic airway inflammation (AAI) and asthma, pulmonary fibrosis, lung cancer, chronic obstructive pulmonary disease (COPD), acute lung injury, pneumonia, cystic fibrosis, and bronchopulmonary dysplasia. RAGE has not yet been targeted in the lungs of paediatric or adult clinical populations, but the development of new ways to inhibit RAGE is setting the stage for the emergence of novel therapeutic agents for patients suffering from these pulmonary conditions.
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