Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors
Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors
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DOI：
10.1016/j.ejrad.2020.109047
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发表时间：
2020-08-01
影响因子：
3.3
通讯作者：
Yabuuchi, Hidetake
中科院分区：
文献类型：
--
作者：
Kamitani, Takeshi;Sagiyama, Koji;Yabuuchi, Hidetake
目的：评估酰胺质子转移 (APT) 成像在鉴别腮腺肿瘤中的有用性。材料和方法：我们回顾性分析了 43 个经组织病理学证实的直径 >= 2 cm 的腮腺实体瘤。 21 个肿瘤是良性的，12 个肿瘤是恶性的。使用持续时间为 2 s 的饱和脉冲和 2 mu T 的饱和功率水平进行二维 APT 成像。为了获取 Z 谱，以 0.5 ppm 的步长在 omega = -6 至 +6 ppm 的 25 个饱和频率偏移下重复成像，并获得一次扫描以进行远偏共振 (-1560 ppm) 以进行信号归一化。对于 APT 成像，计算了水信号低场 3.5 ppm 处的不对称性分析。比较良性肿瘤和恶性肿瘤之间的平均 APT 信号强度 (SI)。结果：良性肿瘤的平均 APT SI 为 2.23 +/- 0.80 %，而恶性肿瘤的平均 APT SI 为 2.99 +/- 0.99 %（P = 0.01）。受试者工作曲线分析显示，区分恶性肿瘤和良性肿瘤的最佳APT SI阈值为2.40，曲线下面积为0.74。敏感性、特异性和准确性分别为83.3%、61.3%和67.4%。结论：腮腺恶性肿瘤的平均APT SI显着高于腮腺良性肿瘤。
Purpose: To assess the usefulness of amide proton transfer (APT) imaging in differentiating parotid tumors.Material and methods: We retrospectively analyzed 43 histopathologically proven parotid solid tumors with diameters >= 2 cm. Twenty-one tumors were benign and 12 tumors were malignant. Two-dimensional APT imaging was performed using a saturation pulse with a duration of 2 s and a saturation power level of 2 mu T. For acquiring Z-spectra, the imaging was repeated at 25 saturation frequency offsets from omega = -6 to +6 ppm with a step of 0.5 ppm as well as one scan acquired far off-resonance ( -1560 ppm) for signal normalization. For the APT imaging, the asymmetry analysis at 3.5 ppm downfield from the water signal was calculated. The mean APT signal intensity (SI) was compared between the benign and malignant tumors.Results: The mean APT SI was 2.23 +/- 0.80 % in the benign tumors and significantly higher at 2.99 +/- 0.99 % in the malignant tumors (P = 0.01). A receiver operating curve analysis revealed that the optimal APT SI threshold was 2.40 for distinguishing malignant tumors from benign tumors with an area under the curve of 0.74. The sensitivity, specificity, and accuracy were 83.3%, 61.3%, and 67.4%, respectively.Conclusion: The mean APT SI of the malignant parotid tumors was significantly higher than that of the benign parotid tumors.