Idiopathic Deciduous Skin
Idiopathic Deciduous Skin
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特发性乳叶皮肤
DOI：
10.1111/j.1365-4362.1982.tb02094.x
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发表时间：
1982
影响因子：
3.6
通讯作者：
S. Sengupta
中科院分区：
文献类型：
--
作者：
S. K. Panja;S. Sengupta
5例患者描述或多或少连续脱皮，在夏季加重。没有家庭成员受到影响，受影响个体的父母之间没有血缘关系。特点是手掌、脚底、粘膜和头皮不会脱落。通常患者看起来很脏，偶尔会出现红斑和水泡。男女都受到同样的影响。该病并非在出生时发病，发病可能会延迟。组织病理学检查显示角膜下大泡形成修复，无棘层溶解。角质层显得非常松散，角化过度（或角化过度）。治疗是无效的，除了轻微的角膜溶解使美容改善。病因尚不清楚。可能与自身免疫机制有关。作者建议将这个独特的新皮肤实体命名为“特发性落叶性皮肤”。
Five patients are described with more or less continuous peeling of the skin aggravating in summer months. No family members are affected and consanguinity among parents of affected individuals is not seen. Characteristically the palms, soles, mucous membrane, and scalp are spared from shedding. Generally the patients look dirty and occasional erythema and vesiculation occur. Both sexes are affected equally. The disease does not start at birth and the onset may be delayed. Histopathologic examination shows subcorneal reparation of bulla formation without acantholysis. The stratum corneum appears very loose and shows little hyperkeratosis (or‐thokeratosis). Treatment is ineffective except mild keratolytics give cosmetic improvement. Etiology remains unknown. An autoimmune mechanism may be implicated. The authors propose the name ‘idinpathic deciduous skin’ for this distinct new dermatologic entity.