Multidrug and toxic compound extrusion (MATE)-type proteins as anchor transporters for the excretion of metabolic waste products and xenobiotics
Multidrug and toxic compound extrusion (MATE)-type proteins as anchor transporters for the excretion of metabolic waste products and xenobiotics
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DOI：
10.1080/00498250701883753
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发表时间：
2008-01-01
期刊：
影响因子：
1.8
通讯作者：
Omote, H.
中科院分区：
文献类型：
--
作者：
Moriyama, Y.;Hiasa, M.;Omote, H.
1.多药毒性化合物外排转运蛋白（MATE）是最早被发现的细菌药物转运蛋白家族，存在于几乎所有的原核生物和真核生物中，是自然界中最保守的转运蛋白家族之一.最近，哺乳动物MATE转运蛋白被证明是一个长期假设的电中性H+/有机阳离子出口商，负责排泄代谢废物和外源性物质在肾刷状缘膜和胆小管。植物MATE型转运蛋白通过其在质膜上的囊泡储存或挤出参与金属和次生代谢物如酚类的解毒.因此，MATE转运蛋白参与了通过排泄代谢废物和外源性物质来维持体内平衡的基本机制之一。
1. Multidrug and toxic compound extrusion (MATE)-type transporters, which were first identified as a bacterial drug transporter family, are present in almost all prokaryotes and eukaryotes, and are thus one of the mostly conserved transporter families in nature.2. Recently, a mammalian MATE transporter was shown to be a long hypothesized electroneutral H+/organic cation exporter that is responsible for the excretion of metabolic waste products and xenobiotics at renal brush border membranes and bile canaliculi. Plant MATE-type transporters are involved in the detoxification of metals and secondary metabolites such as phenols through their vesicular storage or extrusion at the plasma membrane.3. Thus, MATE transporters are involved in one of the basic mechanisms that maintain homeostasis through the excretion of metabolic waste products and xenobiotics in nature.