Impact of race on heart rate characteristics monitoring in very low birth weight infants.
Impact of race on heart rate characteristics monitoring in very low birth weight infants.
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DOI：
10.1038/s41390-023-02470-z
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发表时间：
2023-08
影响因子：
3.6
通讯作者：
Fairchild, Karen D.
中科院分区：
文献类型：
--
作者：
Sullivan, Brynne A.;Hochheimer, Camille J.;Chernyavskiy, Pavel;King, William E.;Fairchild, Karen D.
A multicenter RCT showed that displaying a heart rate characteristics index (HRCi) predicting late-onset sepsis reduced mortality for VLBW infants. We aimed to assess whether HRCi display had a differential impact for Black versus White infants. We performed secondary data analysis of Black and White infants enrolled in the HeRO RCT. We evaluated the predictive performance of the HRCi for infants with Black or White maternal race. Using models adjusted for birthweight, we assessed outcomes and interventions for a race × randomization interaction. Among 2,607 infants, Black infants had lower birthweight, gestational age, length of stay, and ventilator days, while sepsis and mortality were similar. The HRCi performed equally for sepsis prediction in Black and White infants. We found no differential effect of randomization by race on sepsis, mortality, antibiotic days, length of stay, or ventilator days. However, there was a differential randomization effect by race for blood cultures per patient: White RR 1.11 (95% CrI 1.04-1.18), Black RR 1.00 (0.93-1.07). The HRCi performed similarly for sepsis prediction in Black and White infants. Randomization to HRCi display increased blood cultures in White but not Black infants, while the impact on other outcomes or interventions was similar.
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DOI：
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发表时间：
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