In vitro activity of biapenem against recent gram-negative and gram-positive clinical isolates
In vitro activity of biapenem against recent gram-negative and gram-positive clinical isolates
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DOI：
10.1159/000239597
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发表时间：
1997-11-01
期刊：
影响因子：
3.3
通讯作者：
Nicoletti, G
中科院分区：
文献类型：
--
作者：
Bonfiglio, G;Maccarone, G;Nicoletti, G
比较了一种新的碳青霉烯类抗生素比阿培南与其他抗生素的体外抗菌活性。比亚培南对革兰氏阴性和革兰氏阳性临床分离株具有广谱抗菌活性。新的碳青霉烯类抗生素对肠杆菌科细菌的MIC90为0.12~2 mg/L，亚胺培南为0.25~4 mg/L。对铜绿假单胞菌的MIC90、MIC8和MIC16 mg/L分别是亚胺培南的2倍。综上所述，这些结果表明比阿培南具有亚胺培南良好的体外活性，在治疗由多种病原体引起的感染方面值得进一步研究。
The in vitro activity of biapenem, a new carbapenem, against 535 clinical recent isolates was compared with those of other antibiotics. Biapenem showed broad-spectrum activity against gram-negative and gram-positive clinical isolates. The new carbapenem was more active than imipenem against members of the family Enterobacteriaceae with MIC90S ranging from 0.12 to 2 mg/l and from 0.25 to 4 mg/l, respectively. Moreover it was 2-fold more active than imipenem against Pseudomonas aeruginosa (MIC90, 8 and 16 mg/l, respectively). Taken together, these results indicate that biapenem shares the favorable in vitro activity properties of imipenem and merits further study in the treatment of infections caused by a wide range of pathogens.