Nonconvulsive seizures in patients presenting with altered mental status: an evidence-based review.

Nonconvulsive seizures in patients presenting with altered mental status: an evidence-based review.
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DOI:
10.1016/j.yebeh.2011.06.012
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发表时间:
2011-10
期刊:
Epilepsy & behavior : E&B
影响因子:
--
通讯作者:
Grant AC
Grant AC
中科院分区:
其他
文献类型:
--
作者:
Zehtabchi S;Abdel Baki SG;Malhotra S;Grant AC

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非惊厥性发作(NCS)的确诊只能通过脑电图进行,延误诊断会增加发病率、资源利用率和住院时间。我们进行了循证文献综述,以估计不明原因的精神状态改变(AMS)患者中NCS的患病率。在PUBMED、EMBASE、科克伦图书馆和其他资源中检索以AMS和癫痫发作为主题的研究。根据预先确定的纳入和排除标准筛选了276篇文章,剩下5项研究纳入了478例患者进行审查。AMS患者中NCS的患病率范围为8%-30%(总体患病率为21.5%; 95%CI,18%-25%),表明NCS的患病率足够高,可以考虑对此类患者常规使用紧急EEG。然而,方法上的缺陷限制了结果的普遍性。需要进行一项大型前瞻性研究,招募和筛查所有急性AMS患者的NCS。
Definitive diagnosis of non-convulsive seizure (NCS) can be made only by EEG, and delay in diagnosis can increase morbidity, resource utilization, and length of hospitalization. We performed an evidence-based literature review to estimate the prevalence of NCS in patients with altered mental status (AMS) of unknown cause. PUBMED, EMBASE, the Cochrane Library and other resources were searched for studies that included AMS and seizure as topics. The resulting 276 articles were screened for predetermined inclusion and exclusion criteria, leaving five studies enrolling 478 patients for review. The prevalence of NCS in AMS patients ranged from 8% to 30% (overall prevalence of 21.5%; 95%CI, 18%–25%), suggesting that the prevalence of NCS is sufficiently high to consider routine use of urgent EEG in such patients. However, methodological weaknesses limit the generalizability of the results. A large, prospective study enrolling and screening for NCS all patients who present with acute AMS is needed.
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