Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors.
Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors.
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DOI：
10.1016/j.omto.2021.12.018
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发表时间：
2022-03-17
期刊：
影响因子：
--
通讯作者：
Srimathveeralli G
中科院分区：
文献类型：
--
作者：
Kimura Y;Ghosn M;Cheema W;Adusumilli PS;Solomon SB;Srimathveeralli G
嵌合抗原受体 (CAR) T 细胞的过继细胞疗法已被证明对血液恶性肿瘤有效，但实体瘤的成功却因瘤内浸润不良、效应细胞因抗原负荷而耗尽以及免疫抑制的肿瘤微环境而受到阻碍。最近的临床试验和临床前研究的结果为 CAR T 细胞递送、启动肿瘤微环境以及进行维持 T 细胞活性的辅助治疗的局部方法提供了有希望的证据。介入肿瘤学是介入放射学的一个分支专业，其中影像引导用于执行经皮和导管引导的手术，以进行实体瘤的局部、非手术治疗或询问。介入肿瘤学与免疫疗法具有独特的协同作用，免疫疗法已被充分研究以提高治疗效果，同时减少与全身治疗相关的毒性。除了帮助 CAR T 细胞递送、启动或刺激肿瘤微环境以促进效应细胞存活和功能外，介入肿瘤学还可以通过选择性、多重肿瘤采样和基于导管的静脉采样来帮助监测治疗反应。这篇综述概述了介入肿瘤学、其各种程序及其推进实体瘤 CAR T 细胞免疫疗法的潜力。介入肿瘤学可以通过局部方法改善生物分布，同时减少全身毒性，从而推进实体瘤的过继细胞治疗。介入肿瘤学技术可以通过选择性静脉取样或多灶性活检帮助准确监测治疗结果，从而为嵌合抗原受体 T 细胞进入和发挥功能奠定基础。
Adoptive cell therapy with chimeric antigen receptors (CAR) T cells has proven effective for hematologic malignancies, but success in solid tumors has been impeded by poor intratumoral infiltration, exhaustion of effector cells from antigen burden, and an immunosuppressive tumor microenvironment. Results from recent clinical trials and preclinical studies lend promising evidence of locoregional approaches for CAR T cell delivery, priming the tumor microenvironment, and performing adjuvant therapies that sustain T cell activity. Interventional oncology is a subspeciality of interventional radiology where imaging guidance is used to perform percutaneous and catheter-directed procedures for localized, non-surgical therapy or interrogation of solid tumors. Interventional oncology provides unique synergies with immunotherapy, which has been well-studied to improve treatment efficacy while reducing toxicities associated with systemic treatment. Besides aiding in CAR T cell delivery, priming, or the stimulation of the tumor microenvironment to promote effector survival and function, interventional oncology can also aid in the monitoring of treatment response through selective, multiplex tumor sampling and catheter-based venous sampling. This review presents an overview of interventional oncology, its various procedures, and its potential for advancing CAR T cell immunotherapy of solid tumors. Interventional oncology can advance adoptive cell therapy of solid tumors through locoregional approaches that improve biodistribution while reducing systemic toxicities. Interventional oncology techniques can prime the tumor microenvironment for chimeric antigen receptor T cell entry and function by aiding accurate monitoring of therapeutic outcomes by selective venous sampling or multifocal biopsy.
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DOI：
10.1016/j.jvir.2014.08.027
发表时间：
2014-11
期刊：
Journal of vascular and interventional radiology : JVIR
影响因子：
--
作者：
Ahmed M;Solbiati L;Brace CL;Breen DJ;Callstrom MR;Charboneau JW;Chen MH;Choi BI;de Baère T;Dodd GD 3rd;Dupuy DE;Gervais DA;Gianfelice D;Gillams AR;Lee FT Jr;Leen E;Lencioni R;Littrup PJ;Livraghi T;Lu DS;McGahan JP;Meloni MF;Nikolic B;Pereira PL;Liang P;Rhim H;Rose SC;Salem R;Sofocleous CT;Solomon SB;Soulen MC;Tanaka M;Vogl TJ;Wood BJ;Goldberg SN;International Working Group on Image-Guided Tumor Ablation;Interventional Oncology Sans Frontières Expert Panel;Technology Assessment Committee of the Society of Interventional Radiology;Standard of Practice Committee of the Cardiovascular and Interventional Radiological Society of Europe
通讯作者：
Standard of Practice Committee of the Cardiovascular and Interventional Radiological Society of Europe
影响因子：
50.3
作者：
Anderson KG;Stromnes IM;Greenberg PD
通讯作者：
Greenberg PD
影响因子：
3.8
作者：
Craciun, Ligia;de Wind, Roland;Donckier, Vincent
通讯作者：
Donckier, Vincent
DOI：
10.1007/s00259-015-3264-6
发表时间：
2016-07-01
影响因子：
9.1
作者：
Barbier, Charlotte Ebeling;Garske-Roman, Ulrike;Granberg, Dan
通讯作者：
Granberg, Dan
影响因子：
4.4
作者：
Ayaru, Lakshmana;Pereira, Stephen P.;Behboudi, Shahriar
通讯作者：
Behboudi, Shahriar