Transient Receptor Potential (TRP) Channels.
Transient Receptor Potential (TRP) Channels.
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DOI：
10.1007/978-981-10-7757-9_6
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发表时间：
2018
影响因子：
--
通讯作者：
Moiseenkova-Bell VY
中科院分区：
文献类型：
--
作者：
Samanta A;Hughes TET;Moiseenkova-Bell VY
瞬时受体电位（TRP）通道是进化上保守的膜蛋白。哺乳动物TRP离子通道超家族由28个阳离子渗透通道组成，根据序列同源性分为6个亚家族（图6.1）。典型的TRP（TRPC）亚家族已知包含哺乳动物TRP通道的创始成员。香草素TRP（TRPV）亚家族由于其创始成员的热敏性而被广泛研究。Melastatin相关的TRP（TRPM）亚家族包括一些已知的双功能离子通道，其中包含功能性酶结构域。锚蛋白TRP（TRPA）亚家族由单个化学伤害感受器组成，其已被提议为镇痛剂的靶标。粘脂蛋白TRP（TRPML）亚家族通道主要存在于细胞内室中，并基于其在IV型粘脂沉积症（ML-IV）中的关键作用而被发现。多囊TRP（TRPP）亚家族是一组与常染色体显性遗传性多囊肾病（ADPKD）有关的蛋白质。总的来说，这个通道超家族参与了大量的生理和病理生理过程，使这些通道的研究对我们理解亚细胞生物化学至关重要。
Transient Receptor Potential (TRP) channels are evolutionarily conserved integral membrane proteins. The mammalian TRP superfamily of ion channels consists of 28 cation permeable channels that are grouped into six subfamilies based on sequence homology (Fig. 6.1). The canonical TRP (TRPC) subfamily is known for containing the founding member of mammalian TRP channels. The vanilloid TRP (TRPV) subfamily has been extensively studied due to the heat sensitivity of its founding member. The melastatin-related TRP (TRPM) subfamily includes some of the few known bi-functional ion channels, which contain functional enzymatic domains. The ankyrin TRP (TRPA) subfamily consists of a single chemo-nociceptor that has been proposed to be a target for analgesics. The mucolipin TRP (TRPML) subfamily channels are found primarily in intracellular compartments and were discovered based on their critical role in type IV mucolipidosis (ML-IV). The polycystic TRP (TRPP) subfamily is a diverse group of proteins implicated in autosomal dominant polycystic kidney disease (ADPKD). Overall, this superfamily of channels is involved in a vast array of physiological and pathophysiological processes making the study of these channels imperative to our understanding of subcellular biochemistry.