A triphasic analysis of corneal swelling and hydration control
A triphasic analysis of corneal swelling and hydration control
复制标题
DOI：
10.1115/1.2798004
复制
发表时间：
1998-06-01
影响因子：
1.7
通讯作者：
McDonnell, PJ
中科院分区：
文献类型：
--
作者：
Bryant, MR;McDonnell, PJ
生理学研究强烈支持这样的观点：角膜的水合控制依赖于角膜内皮的活性离子传输。然而，内皮离子转运调节角膜厚度的机制尚未详细阐述。在这项研究中，角膜基质被建模为稳态条件下的三相材料。开发了离子通量边界条件来表示内皮的主动运输。这些方程在圆柱坐标中求解以进行有限压缩，并在球坐标中求解以表示完整的角膜。该模型提供了一种内皮活性离子传输调节角膜水合的机制，并为解释“吸入压力”和基质“膨胀压力”的起源提供了基础。该模型概括了唐南关于角膜肿胀的观点以及“泵泄漏假说”。
Physiological studies strongly support the view that hydration control in the cornea is dependent on active ion transport ata the corneal endothelium. However, the mechanism by which endothelial ion transport regulates corneal thickness has not been elaborated in detail. In this study, the corneal stroma is modeled as a triphasic material under steady-state conditions. An ion flux boundary condition is developed to represent active transport at the endothelium. the equations are solved in cylindrical coordinates for confined compression and in spherical coordinates to represent an intact cornea. The model provides a mechanism by which active ion transport at the endothelium regulates corneal hydration and provides a basis for explaining the origin of the "imbibition pressure" and stromal "swelling pressure." The model encapsulates the Donnan view of corneal swelling as well as the "pump-leak hypothesis.".