Passive Transport Disrupts Grid Signals in the Parahippocampal Cortex.
Passive Transport Disrupts Grid Signals in the Parahippocampal Cortex.
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DOI：
10.1016/j.cub.2015.08.034
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发表时间：
2015-10-05
期刊：
影响因子：
--
通讯作者：
Taube JS
中科院分区：
文献类型：
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作者：
Winter SS;Mehlman ML;Clark BJ;Taube JS
导航通常被认为是与地标相关的，但代表空间的神经信号也使用动物运动产生的信息。这些信号包括网格单元，这些单元在多个位置激发，形成重复的网格模式。网格细胞的产生依赖于theta节奏，这是一种受动物运动速度调制的6-10赫兹的脑电振荡。我们被动地将老鼠放在一辆干净的手推车里，以消除与运动相关的自我运动线索，这些线索推动着theta节律性的每时每刻的变化。我们发现，被动运动将theta的功率和频率维持在相当于低主动运动速度的水平，避免了整体HD细胞的特征，并取消了theta节律性和网格细胞放电模式的速度调制。这些结果表明，自我运动运动线索对于产生特定于网格的放电模式是必要的，可能是通过驱动速度调节theta节律性。可以使用theta的速度调制作为速度信号来产生网格单元的重复图案。
Navigation is usually thought of relative to landmarks, but neural signals representing space also use information generated by an animal’s movements. These signals include grid cells, which fire at multiple locations forming a repeating grid pattern. Grid cell generation depends upon theta rhythm, a 6-10 Hz EEG oscillation that is modulated by the animals’ movement velocity. We passively moved rats in a clear cart to eliminate motor related self-movement cues that drive moment-to-moment changes in theta rhythmicity. We found that passive movement maintained theta power and frequency at levels equivalent to low active movement velocity, spared overall HD cell characteristics, and abolished velocity modulation of theta rhythmicity and grid cell firing patterns. These results indicate that self-movement motor cues are necessary for generating grid-specific firing patterns, possibly by driving velocity modulation of theta rhythmicity. Velocity modulation of theta may be used as a speed signal to generate the repeating pattern of grid cells.