Effects of pindolol and propranolol on beta-adrenergic receptors on human lymphocytes.
Effects of pindolol and propranolol on beta-adrenergic receptors on human lymphocytes.
复制标题
吲哚洛尔和普萘洛尔对人淋巴细胞β-肾上腺素能受体的影响。
DOI：
10.1111/j.1365-2125.1982.tb01942.x
复制
发表时间：
1982
影响因子：
3.4
通讯作者：
M. Goens
中科院分区：
文献类型：
--
作者：
P. Molinoff;R. Aarons;A. Nies;J. Gerber;B. Wolfe;M. Goens
The cardiovascular supersensitivity observed after discontinuation of administration of beta adrenergic receptor antagonists may be explained by an increase in the density of beta adrenergic receptors. Thus, a change in the density of receptors has been observed in human lymphocytes after administration of propranolol (Aarons et al., 1980). The effects of pindolol, a beta adrenergic receptor antagonist with intrinsic sympathomimetic activity, were compared with those of propranolol or placebo. Pindolol (10 mg q.i.d.), propranolol (40 mg q.i.d.) or placebo were administered to 12 subjects for 8 days. The density of beta adrenergic receptors was determined by Scatchard analysis of the specific binding of [125I]iodopindolol on membranes prepared from human lymphocytes. Administration of pindolol resulted in a 30 to 50% decrease in the density of beta adrenergic receptors. This decrease was apparent within 1 day of beginning pindolol administration and it persisted for at least 8 days after discontinuation of drug administration. The reversibility of the decrease in receptors observed after pindolol administration was studied in 27 subjects given propranolol, pindolol or placebo for 4 days in a double-blind cross-over trial. Propranolol consistently induced a small increase in the density of beta adrenergic receptors. The density of receptors returned to predrug values within 2 days after discontinuation of propranolol administration. Pindolol induced a 30 to 50% decrease in the density of receptors which, as observed previously, persisted for at least 10 days after discontinuation of treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
