Dendritic saccharide surfactant polymers as antifouling interface materials to reduce platelet adhesion.
Dendritic saccharide surfactant polymers as antifouling interface materials to reduce platelet adhesion.
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DOI：
10.1021/bm050611p
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发表时间：
2006-03
影响因子：
6.2
通讯作者：
Junmin Zhu;R. Marchant
中科院分区：
文献类型：
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作者：
Junmin Zhu;R. Marchant
在这里，我们报告的树枝状糖表面活性剂聚合物的合成作为血小板界面材料，以减少血小板粘附。首先以氨基乙醛缩二甲醇（1）为原料合成了一种缩醛保护的聚酰胺-胺（PAMAM）树枝状分子（5，G = 2），以提供一种具有二甲醇缩二甲醇保护的醛官能团的单价焦点结构。麦芽糖树枝化基元（M4，6）是通过缩醛树枝化基元（5）的外围胺基与麦芽糖内酯反应而得到的。树枝状表面活性剂聚合物（9）然后经由两步法通过依次添加麦芽糖树枝化基和己醛以与聚（乙烯胺）（PVAm）主链上的胺基反应来合成。两亲性糖基共聚物在空气/水界面处的表面活性通过水表面张力的降低来证明。通过水接触角测量研究了两亲性糖基共聚物在十八烷基三氯硅烷（OTS）涂层盖玻片上的固/水界面吸附。利用原子力显微镜在流体轻敲模式下对树枝状表面活性剂聚合物在高取向热解石墨（HOPG）上的表面诱导自组装进行了纳米尺度的研究。吸附表面活性剂聚合物的横向排序是可视化的，具有60度排列的链中的图案。静态血小板粘附测试表明，己基侧链可以促进表面活性剂聚合物吸附到疏水基底上，而麦芽糖树枝状侧链可以提供保护性糖萼样层的致密树冠作为粘附界面以减少血小板粘附。
Here, we report on the synthesis of dendritic saccharide surfactant polymers as antifouling interface materials to reduce platelet adhesion. An acetal-protected poly(amidoamine) (PAMAM) dendron (5, G = 2) was first synthesized by using aminoacetaldehyde dimethyl acetal (1) as the starting material to provide a monovalent focal structure with dimethyl acetal-protected aldehyde functionality. Maltose dendron (M4, 6) was obtained by reacting the peripheral amine groups of acetal-dendron (5) with maltonolactone. The dendritic surfactant polymers (9) were then synthesized via a two-step method by sequential addition of maltose dendron and hexanal to react with the amine groups on the poly(vinylamine) (PVAm) backbone. Surface activity of the amphiphilic glycopolymers at the air/water interface was demonstrated by reduction in water surface tension. Adsorption of the amphiphilic glycopolymers at the solid/water interface was examined on octadecyltrichlorosilane (OTS)-coated coverslips by water contact angle measurements. A nanoscale understanding of surface-induced self-assembly of the dendritic surfactant polymer on highly oriented pyrolytic graphite (HOPG) was gained using AFM operated in fluid tapping mode. A lateral ordering of adsorbing surfactant polymer was visualized with a pattern in strands 60 degrees out of alignment. The static platelet adhesion tests show that the hexyl side chains can facilitate adsorption of the surfactant polymers onto hydrophobic substrates, while the maltose dendron side chains can provide a dense canopy of protective glycocalyx-like layer as an antifouling interface to reduce platelet adhesion.