Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention.
Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention.
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癌症化学预防中选定的饮食植物化学物质的表观遗传学调节。
DOI：
10.1016/j.canlet.2014.09.017
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发表时间：
2014-12-01
期刊：
影响因子：
9.7
通讯作者：
Katiyar, Santosh K.
中科院分区：
文献类型：
--
作者：
Shukla, Samriddhi;Meeran, Syed M.;Katiyar, Santosh K.
对癌症表观遗传学日益增长的兴趣在很大程度上是由于表观遗传学变化的可逆性，这些变化在癌变过程中往往会改变。主要的表观遗传学改变包括DNA甲基化、染色质修饰和miRNA调控在肿瘤发生过程中起重要作用。有几种表观遗传活性合成分子，如DNA甲基转移酶（DNMT）和组蛋白脱乙酰酶（HDAC）抑制剂，它们已被批准或正在临床试验中用于治疗各种癌症。然而，大多数合成的抑制剂都显示出不良的副作用，其特异性狭窄，并且价格昂贵。因此，生物活性的植物化学物质，这是广泛使用的毒性较小的影响，已经测试了它们的作用，在癌症预防和治疗的基因调控的表观遗传调节活性。令人鼓舞的是，许多生物活性的植物化学物质通过调节癌症中的DNA甲基化和染色质修饰，潜在地改变了关键肿瘤抑制基因、肿瘤启动子基因和癌基因的表达。这些生物活性植物化学物质单独或与其他植物化学物质组合显示出对各种癌症的有希望的结果。在这里，我们总结并讨论了一些常见的研究植物化学物质及其表观遗传靶点的作用，这些靶点在癌症预防和癌症治疗中特别重要。
The growing interest in cancer epigenetics is largely due to the reversible nature of epigenetic changes which tend to alter during the course of carcinogenesis. Major epigenetic changes including DNA methylation, chromatin modifications and miRNA regulation play important roles in tumorigenic process. There are several epigenetically active synthetic molecules such as DNA methyltransferase (DNMTs) and histone deacetylases (HDACs) inhibitors, which are either approved or, are under clinical trials for the treatment of various cancers. However, most of the synthetic inhibitors have shown adverse side effects, narrow in their specificity and also expensive. Hence, bioactive phytochemicals, which are widely available with lesser toxic effects, have been tested for their role in epigenetic modulatory activities in gene regulation for cancer prevention and therapy. Encouragingly, many bioactive phytochemicals potentially altered the expression of key tumor suppressor genes, tumor promoter genes and oncogenes through modulation of DNA methylation and chromatin modification in cancer. These bioactive phytochemicals either alone or in combination with other phytochemicals showed promising results against various cancers. Here, we summarize and discuss the role of some commonly investigated phytochemicals and their epigenetic targets that are of particular interest in cancer prevention and cancer therapy.
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影响因子：
11.5
作者：
Baliga, MS;Meleth, S;Kadiyar, SK
通讯作者：
Kadiyar, SK
DOI：
10.1006/bbrc.2000.3297
发表时间：
2000-08-28
影响因子：
3.1
作者：
Ahmad, N;Cheng, PY;Mukhtar, H
通讯作者：
Mukhtar, H
影响因子：
5.7
作者：
Hsu A;Wong CP;Yu Z;Williams DE;Dashwood RH;Ho E
通讯作者：
Ho E
影响因子：
--
作者：
Chen H;Landen CN;Li Y;Alvarez RD;Tollefsbol TO
通讯作者：
Tollefsbol TO
影响因子：
4.2
作者：
Day, JK;Bauer, AM;Lubahn, DB
通讯作者：
Lubahn, DB