Correcting an immune-response deficiency by creating Eα gene transgenic mice
Correcting an immune-response deficiency by creating Eα gene transgenic mice
复制标题
通过创建 Eα 基因转基因小鼠来纠正免疫反应缺陷
作者：
M. L. Meur;P. Gerlinger;C. Benoist;D. Mathis
我们将克隆的Ekα基因导入不能表达内源性Eα基因的小鼠胚胎中。Ekα在转基因细胞系中的转录是准确的和组织特异性的，并且在巨噬细胞中，Ekα的转录可以被γ-干扰素诱导。注入的基因赋予遗传缺陷的宿主菌株对合成聚合物产生免疫反应的能力。
We have introduced a cloned Ekα gene into embryos of mice incapable of expressing their endogenous Eα genes. The transcription of Ekα was accurate and tissue-specific in the resulting transgenic lines and, in macrophages, Ekα transcription could be induced by γ-interferon. The injected gene conferred on the genetically deficient host strain the ability to mount an immune response to a synthetic polymer.
4 号染色体 Jt 基因控制小鼠 T 细胞表面 I-J 表达。
DOI：
10.1126/science.6607530
发表时间：
1984
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hayes,CE;Klyczek,KK;Krum,DP;Whitcomb,RM;Hullett,DA;Cantor,H
通讯作者：
Cantor,H