Alcohol for Surgical Scrubbing?
Alcohol for Surgical Scrubbing?
复制标题
手术擦洗用酒精吗？
DOI：
10.2307/30145476
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发表时间：
1990
影响因子：
4.5
通讯作者：
Barbara A. Laughon
中科院分区：
文献类型：
--
作者：
E. Larson;A. Butz;D. Gullette;Barbara A. Laughon
为测试4种外科擦洗产品对手部菌群定植的影响，60名健康成年志愿者按整群随机分组(每组12人)，分别使用以下配方中的一种：70%乙醇加0.5%葡萄糖酸氯己定(ALC)；含1%三氯生(TRI)的洗涤剂基液；含4%葡萄糖酸氯己定(CHG)的洗涤剂基液；含7.5%聚维酮碘(PI)的洗涤剂基液；或非抗菌液体肥皂(对照组)。使用标准方案，受试者连续五天每天进行手术擦洗。手部培养在基线时、擦洗后立即测试的第1天和第5天以及戴手套4小时后获得。在第一次和最后一次灌丛后，与对照相比，ALC、CHG和PI显著减少了定殖菌群。此外，到第5天时，ALC几乎减少了3个对数，而CHG和PI大约减少了1.5个对数，低于TRI和对照组的L-对数减少(p=0.009)。在第一天和第五天戴手套四个小时后，使用ALC、TRI和CHG的受试者手上的微生物计数显著低于对照组(p<；.001)，而PI组和对照组之间的微生物计数没有显著差异(p=.41)。研究对象对皮肤的评估从最轻到最苛刻依次为：控制、TRI、CHG、ALC和PI(p=.00001)。结论：ALC是一种有效的、可接受的外科擦洗方法。
Abstract To test the effects of four surgical scrub products on colonizing hand flora, 60 healthy adult volunteers were assigned by block randomization (12 subjects per group) to use one of the following formulations: 70% ethyl alcohol with 0.5% chlorhexidine gluconate (ALC); a liquid detergent base containing 1% triclosan (TRI); a liquid detergent base containing 4% chlorhexidine gluconate (CHG); a liquid detergent base containing 7.5% povidone-iodine (PI); or a nonantimicrobial liquid soap (control). Using standard protocol, subjects performed a surgical scrub daily for five consecutive days. Hand cultures were obtained at baseline and on test days 1 and 5 immediately after the scrub and following four hours of gloving. After the first and last scrubs, ALC, CHG and PI resulted in significant reductions in colonizing flora when compared to the control. Additionally, by day 5 ALC was associated with an almost 3-log reduction as compared to an approximate 1.5-log reduction for CHG and PI and less than a l-log reduction of TRI and the control (p = .009). After four hours of gloving on both days 1 and 5, microbial counts on hands of subjects using ALC, TRI and CHG were significantly lower than counts for the control (p < .001), whereas there was no significant difference in counts between the PI and control groups (p = .41). Skin assessment by study subjects rated products from least to most harsh as follows: control, TRI, CHG, ALC and PI (p = .00001). It was concluded that ALC could be an efficacious and acceptable alternative for surgical scrubbing.