Epidemiology of central nervous system tumors in children and young adults (0-29 years), Yorkshire, United Kingdom
Epidemiology of central nervous system tumors in children and young adults (0-29 years), Yorkshire, United Kingdom
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DOI：
10.1080/08880010490501079
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发表时间：
2004-10-01
影响因子：
1.7
通讯作者：
McKinney, P
中科院分区：
文献类型：
--
作者：
Feltbower, R;Picton, S;McKinney, P
作者描述了1990至2001年间在英国约克郡被诊断为30岁以下的480名中枢神经系统肿瘤患者的发病率和存活率。研究剥夺和其他预后因素对存活率的影响。年轻人(15-29岁)发生中枢神经系统肿瘤的可能性明显低于儿童(p=.001)，这主要是因为在儿童年龄范围内髓母细胞瘤和室管膜瘤过多。除了年轻人外，其他中枢神经系统肿瘤的发病率没有明显的时间趋势。其他中枢神经系统肿瘤的平均年增长率为10.7%(95%可信区间1.3-21.0%；p=.03)。年轻人的存活率显著低于儿童(风险比=1.52，95%可信区间1.10-2.10)。死亡风险最高的是来自最富裕地区的患者。中枢神经系统肿瘤的总体负担似乎相对恒定，但年轻人的生存率明显较低，需要进一步快速调查。
The authors describe the incidence and survival of 480 patients diagnosed under 30 years with a CNS tumor in Yorkshire, UK between 1990 and 2001. The effect on survival from deprivation and other prognostic factors was examined. Young adults (aged 15-29) were significantly less likely to develop CNS tumors than children (p=.001), largely because of an excess of medulloblastoma and ependymoma in the pediatric age range. No significant temporal trends in incidence were present apart from young adults with "other CNS tumors showing an average annual increase of 10.7% (95% CI 1.3-21.0%; p=.03). Young adults had significantly lower survival rates than children (hazard ratio = 1.52, 95% CI 1.10-2.10). The highest risk of death was observed for patients from the most affluent areas. The overall burden of CNS tumors appears to be relatively constant, but the significantly poorer survival for young people needs further rapid investigation.