Cytokeratin 7: a useful adjunct in the diagnosis of chromophobe renal cell carcinoma
Cytokeratin 7: a useful adjunct in the diagnosis of chromophobe renal cell carcinoma
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DOI：
10.1046/j.1365-2559.2002.01397.x
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发表时间：
2002-06-01
期刊：
影响因子：
6.4
通讯作者：
O'Donnell, M
中科院分区：
文献类型：
--
作者：
Mathers, ME;Pollock, AM;O'Donnell, M
目的：嫌色细胞肾细胞癌的组织病理学诊断可能存在诊断挑战，因为这些肿瘤可能类似于传统的肾细胞癌或嗜酸细胞瘤。本研究的目的是确定是否细胞角蛋白7的表达是实际使用的区分这三个entities.Methods和结果：共40例先前诊断为嫌色细胞肾细胞癌，常规肾细胞癌或嗜酸细胞瘤被确定。每个的代表性切片用H&E和细胞角蛋白7染色。由三位病理学家对病例进行独立审查后，对每例病例达成一致诊断，并对细胞角蛋白7染色模式进行评估。有12例嫌色细胞肾细胞癌的研究，所有这些都表现出特征性的细胞角蛋白7染色的外周膜模式。18例常规肾细胞癌中17例细胞角蛋白7阴性，1例细胞角蛋白7呈弱灶性染色。
Aims: The histopathological diagnosis of chromophobe renal cell carcinoma can present a diagnostic challenge, as these tumours can resemble either conventional renal cell carcinoma or oncocytoma. The aim of this study was to determine whether cytokeratin 7 expression is of practical use in the distinction of these three entities.Methods and results: A total of 40 cases previously diagnosed as either chromophobe renal cell carcinoma, conventional renal cell carcinoma or oncocytoma were identified. A representative section of each was stained with H&E and cytokeratin 7. Following independent review of the cases by three pathologists, a consensus diagnosis for each case was reached and the pattern of cytokeratin 7 staining was assessed. There were 12 cases of chromophobe renal cell carcinoma in the study, all of which showed a characteristic peripheral membrane pattern of staining for cytokeratin 7. Seventeen of the 18 cases of conventional renal cell carcinoma studied were negative for cytokeratin 7, while one case showed weak focal staining of