Localization of a gene that escapes inactivation to the X chromosome proximal short arm: implications for X inactivation.
Localization of a gene that escapes inactivation to the X chromosome proximal short arm: implications for X inactivation.
复制标题
逃避失活的基因定位于 X 染色体近端短臂：对 X 失活的影响。
DOI：
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发表时间：
1990
影响因子：
9.8
通讯作者：
H. Willard
中科院分区：
文献类型：
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作者：
C. Brown;H. Willard
哺乳动物X染色体失活的过程导致雌性动物两条X染色体中沿着一条或另一条上的大部分（但不是全部）基因失活。在人类X染色体上，已经描述了几个基因“逃脱”失活并继续从两个同源物表达。所有这些先前定位的基因都位于X染色体短臂的远端三分之一，这就产生了染色体上有一个区域在发育过程中保持非失活的假设。A1 S9 T基因是一个X连锁的基因座，它补充了小鼠DNA合成中的温度敏感性缺陷，逃脱了失活，现在已经在人-小鼠体细胞杂交中定位于Xp11.1至Xp11.3的近端短臂。因此，A1 S9 T位于染色体的一个区域，该区域与已知逃避失活的其他基因分开，并且位于已知受到X失活的其他基因之间。这一发现排除了基于单个染色体区域逃避失活的模型，并表明X失活通过一种机制进行，该机制允许染色体上不同基因或区域之间具有相当大的自主性。
The process of mammalian X chromosome inactivation results in the inactivation of most, but not all, genes along one or the other of the two X chromosomes in females. On the human X chromosome, several genes have been described that "escape" inactivation and continue to be expressed from both homologues. All such previously mapped genes are located in the distal third of the short arm of the X chromosome, giving rise to the hypothesis of a region of the chromosome that remains noninactivated during development. The A1S9T gene, an X-linked locus that complements a mouse temperature-sensitive defect in DNA synthesis, escapes inactivation and has now been localized, in human-mouse somatic cell hybrids, to the proximal short arm, in Xp11.1 to Xp11.3. Thus, A1S9T lies in a region of the chromosome that is separate from the other genes known to escape inactivation and is located between other genes known to be subject to X inactivation. This finding both rules out models based on a single chromosomal region that escapes inactivation and suggests that X inactivation proceeds by a mechanism that allows considerable autonomy between different genes or regions on the chromosome.
重组人 X 染色体的细胞遗传学和分子研究：对 X 染色体失活传播的影响。
DOI：
10.1073/pnas.84.14.4954
发表时间：
1987
影响因子：
11.1
作者：
Mohandas,T;Geller,RL;Yen,PH;Rosendorff,J;Bernstein,R;Yoshida,A;Shapiro,LJ
通讯作者：
Shapiro,LJ
细胞表面抗原位点 MIC2X 逃脱了 X 失活。
影响因子：
9.8
作者：
Goodfellow,P;Pym,B;Mohandas,T;Shapiro,LJ
通讯作者：
Shapiro,LJ
来自杜氏肌营养不良症携带者的克隆性成肌细胞中的肌营养不良蛋白分析。
影响因子：
9.8
作者：
Hurko,O;Hoffman,EP;McKee,L;Johns,DR;Kunkel,LM
通讯作者：
Kunkel,LM