Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study.
Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study.
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短期暴露于环境空气污染和系统性炎症的生物标志物：弗雷明汉心脏研究。
DOI：
10.1161/atvbaha.117.309799
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发表时间：
2017-09
期刊：
影响因子：
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通讯作者：
Mittleman MA
中科院分区：
文献类型：
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作者：
Li W;Dorans KS;Wilker EH;Rice MB;Ljungman PL;Schwartz JD;Coull BA;Koutrakis P;Gold DR;Keaney JF Jr;Vasan RS;Benjamin EJ;Mittleman MA
研究大波士顿地区弗雷明汉后代和第三代队列参与者短期暴露于环境空气污染与系统性炎症循环生物标志物之间的关系。我们纳入了居住在马萨诸塞州波士顿中心空气污染监测点50公里范围内的3,996名非吸烟参与者（平均年龄53.6岁，54%为女性），并计算了检查前细颗粒物（PM2.5）、黑碳（BC）、硫酸盐、氮氧化物（NOx）和臭氧的1至7天移动平均值。我们使用c反应蛋白（CRP）和肿瘤坏死因子受体2 （TNFR2）的线性混合效应模型，每个参与者最多测量两次；我们对白细胞介素-6、纤维蛋白原和肿瘤坏死因子α (tnf - α)使用线性回归模型，这些数据测量一次。我们根据人口统计、社会经济地位、生活方式、时间和天气进行了调整。PM2.5和硫酸盐的3- 7天移动平均值与CRP浓度呈正相关。5天移动平均PM2.5升高5 μg/m3与循环CRP升高4.2% （95% CI: 0.8, 7.6）相关。NOx与白细胞介素-6呈正相关，BC、硫酸盐和臭氧与TNFR2呈正相关。BC、硫酸盐和NOx与纤维蛋白原呈负相关，硫酸盐与TNFα呈负相关。居住在大波士顿地区的人，短期暴露于相对较低水平的环境空气污染中，与较高水平的CRP、白细胞介素-6和TNFR2有关，但与纤维蛋白原或TNFα无关。
To examine associations between short-term exposure to ambient air pollution and circulating biomarkers of systemic inflammation in participants from the Framingham Offspring and Third Generation cohorts in the Greater Boston area. We included 3,996 non-current smoking participants (mean age 53.6 years, 54% women) who lived within 50 km from a central air pollution monitoring site in Boston, Massachusetts, and calculated the 1- to 7-day moving averages of fine particulate matter (PM2.5), black carbon (BC), sulfate, nitrogen oxides (NOx), and ozone prior to the examination visits. We used linear mixed effects models for C-reactive protein (CRP) and tumor necrosis factor receptor 2 (TNFR2) which were measured up to twice for each participant; we used linear regression models for interleukin-6, fibrinogen, and tumor necrosis factor α (TNFα) which were measured once. We adjusted for demographics, socioeconomic position, lifestyle, time, and weather. The 3- to 7-day moving averages of PM2.5 and sulfate were positively associated with CRP concentrations. A 5 μg/m3 higher 5-day moving average PM2.5 was associated with 4.2% (95% CI: 0.8, 7.6) higher circulating CRP. Positive associations were also observed for NOx with interleukin-6, and for BC, sulfate, and ozone with TNFR2. However, BC, sulfate, and NOx were negatively associated with fibrinogen, and sulfate was negatively associated with TNFα. Higher short-term exposure to relatively low levels of ambient air pollution was associated with higher levels of CRP, interleukin-6, and TNFR2, but not fibrinogen or TNFα, in individuals residing in the Greater Boston area.