Subjective and objective cognitive decline at the pre-dementia stage of Alzheimer's disease
Subjective and objective cognitive decline at the pre-dementia stage of Alzheimer's disease
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DOI：
10.1007/s00406-014-0539-z
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发表时间：
2014-11-01
影响因子：
4.7
通讯作者：
Jessen, Frank
中科院分区：
文献类型：
--
作者：
Jessen, Frank
对阿尔茨海默病（AD）痴呆预测的研究已经从轻度认知障碍阶段发展到AD的临床前阶段。这也将焦点从神经心理学测试测量的认知功能障碍的早期临床体征扩展到未受损老年人认知功能下降（SCD）的纯粹主观报告。流行病学研究表明，客观损害和SCD都是AD痴呆的独立预测因素。两者也与AD的生物标志物或神经影像学证据的可能性增加相关。然而，客观和主观认知表现沿着AD发展轴的关系以及它们在不同阶段预测AD痴呆的作用还没有得到很好的探讨。在痴呆前疾病的不同阶段，这两个方面的优势和劣势的精确知识将有利于痴呆的预测。本文介绍了这两个概念及其相互作用。
Research on Alzheimer's disease (AD) dementia prediction has moved from the mild cognitive impairment stage to the preclinical stage of AD. This has also extended the focus from the early clinical sign of cognitive impairment measured with neuropsychological tests to the purely subjective report of cognitive decline (SCD) in unimpaired elderly individuals. Epidemiological studies have shown that both objective impairment and SCD are independently predictive of AD dementia. Both are also associated with an increased likelihood of biomarker or neuroimaging evidence of AD. However, the relationship of objective and subjective cognitive performance along the axis of AD development and their role at different stages in prediction of AD dementia is not well explored. Refined knowledge about strengths and weaknesses of both aspects at different pre-dementia disease stages will be beneficial for dementia prediction. Both concepts and their interaction are introduced in this article.