Interfering with airway nerves in cough associated with asthma
Interfering with airway nerves in cough associated with asthma
复制标题
DOI：
10.1016/j.pupt.2019.101854
复制
发表时间：
2019-12-01
影响因子：
3.2
通讯作者：
Kanemitsu, Yoshihiro
中科院分区：
文献类型：
--
作者：
Niimi, Akio;Fukumitsu, Kensuke;Kanemitsu, Yoshihiro
咳嗽是哮喘的一种麻烦且通常难治的症状，其与疾病控制不良有关。哮喘性咳嗽的发病机制主要归因于支气管收缩，但最近的证据表明，咳嗽反射超敏反应或神经元功能障碍是哮喘的一个特征，即使在那些病情轻微稳定的患者中也是如此。这可能对抑制典型哮喘反应的主要治疗ICS/LABA具有耐药性。这种顽固性咳嗽可能在白天而不是晚上更明显。讨论了针对神经（LTRAs、噻托溴铵和潜在的支气管热成形术）的哮喘中此类难治性咳嗽或咳嗽反射超敏反应的治疗选择。
Cough is a troublesome and often refractory symptom of asthma, which is associated with poor control of disease. The pathogenesis of asthmatic cough has mainly been attributed to bronchoconstriction, but recent evidence indicate that cough reflex hypersensitivity or neuronal dysfunction is a feature of asthma, even in those with mild stable disease. This is likely resistant to the mainstay treatment ICS/LABA which inhibits classic asthmatic response. Such refractory cough might manifest more predominantly in the day-time rather than night-time. Treatment options of such refractory cough or cough reflex hypersensitivity in asthma targeting the nerves (LTRAs, tiotropium, and potentially bronchial thermoplasty) are discussed.