Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy
Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy
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DOI：
10.1038/s41551-018-0261-7
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发表时间：
2019-01-01
影响因子：
28.1
通讯作者：
Fujie, Toshinori
中科院分区：
文献类型：
--
作者：
Yamagishi, Kento;Kirino, Izumi;Fujie, Toshinori
用于治疗内部病变的节拍（即，低剂量和长期）光动力疗法（mPDT）需要将光学设备稳定固定到内部组织表面，以实现连续的局部光递送。外科缝合--器械固定的标准选择--可能不适合周围主要神经和血管的存在，也不适合脆弱、形状改变或活动的器官或组织。在这里，我们表明，由基于近场通信的发光二极管芯片和生物粘附性和可拉伸聚多巴胺改性的聚（二甲基硅氧烷）纳米片组成的可植入和无线供电的mPDT设备可以稳定地固定在动物组织的内表面上。当皮下植入具有皮内移植肿瘤的小鼠时，该装置通过以比传统PDT方法低约1，000倍的强度照射10天而产生显著的抗肿瘤作用。mPDT设备可能有助于难以检测的微小肿瘤和标准光疗难以到达的深层病变的治疗策略。
Metronomic (that is, low-dose and long-term) photodynamic therapy (mPDT) for treating internal lesions requires the stable fixation of optical devices to internal tissue surfaces to enable continuous, local light delivery. Surgical suturing-the standard choice for device fixation-can be unsuitable in the presence of surrounding major nerves and blood vessels, as well as for organs or tissues that are fragile, change their shape or actively move. Here, we show that an implantable and wirelessly powered mPDT device consisting of near-field-communication-based light-emitting-diode chips and bioadhesive and stretchable polydopamine-modified poly(dimethylsiloxane) nanosheets can be stably fixed onto the inner surface of animal tissue. When implanted subcutaneously in mice with intradermally transplanted tumours, the device led to significant antitumour effects by irradiating for 10d at approximately 1,000-fold lower intensity than conventional PDT approaches. The mPDT device might facilitate treatment strategies for hard-to-detect microtumours and deeply located lesions that are hard to reach with standard phototherapy.