Clinical and immunological characteristics of the emulsion form of inactivated influenza vaccine delivered by oral immunization
Clinical and immunological characteristics of the emulsion form of inactivated influenza vaccine delivered by oral immunization
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DOI：
10.1016/0168-1656(95)00105-0
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发表时间：
1996-01-26
影响因子：
4.1
通讯作者：
Naichin, AN
中科院分区：
文献类型：
--
作者：
Avtushenko, SS;Sorokin, EM;Naichin, AN
由于流感病毒的广泛流行，预防流感病毒引起的人类呼吸道疾病实际上是一个感染病理学问题。本研究对甲型流感（H1N1）、甲型流感（H3N2）和B型流感病毒株制备的口服乳剂灭活疫苗的安全性、反应原性和免疫活性进行了研究。流感乳剂灭活疫苗在志愿者中的临床研究表明其安全性和无反应原性。口服疫苗未引起弱、中、强全身或局部反应，包括临床、生化、血液学和免疫学反应。该乳剂灭活疫苗具有较高的免疫活性，一次口服后，志愿者鼻分泌物和唾液中抗甲型流感病毒和抗B流感病毒分泌型免疫球蛋白A的保护滴度水平可靠升高。结果表明，进一步研究和改进口服流感灭活疫苗是适宜的。
Prophylaxis of human respiratory diseases caused by influenza viruses is actually a problem of infectious pathology because of their wide prevalence. In our investigations, safety, reactogenicity and immunological activity of the orally administered emulsion-inactivated influenza vaccine prepared from influenza virus strains of types A(H1N1), A(H3N2) and B have been studied. Clinical studies of the emulsion-inactivated influenza vaccine on volunteers has shown its safety and nonreactogenicity. The orally administered vaccine did not cause weak, middle or strong general or local reactions including clinical, biochemical, haemotological and immunological reactions. The emulsion-inactivated vaccine has high immunological activity and induces reliable increases in the level of secretory immunoglobulin A to influenza viruses A and B in protective titers in nasal secretions and saliva of volunteers after one oral administration. The obtained results indicate the expediency of further investigation and improvement of inactivated influenza vaccine for oral administration.