Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice
Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice
复制标题
DOI：
10.1016/j.neulet.2007.05.061
复制
发表时间：
2007-07-18
影响因子：
2.5
通讯作者：
Kim, Yong-Sun
中科院分区：
文献类型：
--
作者：
Kim, Boe-Hyun;Jun, Yong-Chul;Kim, Yong-Sun
大量证据表明氧化应激可能参与了传染性海绵状脑病（tse）的发病机制。为了研究铁代谢在tse中的作用，我们检测了痒病感染小鼠中铁调节蛋白（IRPs）、铁蛋白的表达水平以及IRPs与铁反应元件（IRE）的结合活性。我们发现，瘙痒病感染小鼠大脑海马和大脑皮层星形胶质细胞中irps - ire结合活性和铁蛋白增加。这些结果表明，铁代谢的改变有助于神经退行性变的发展，并且在tse发病过程中可能存在一些针对铁诱导氧化损伤的保护机制。2007爱思唯尔爱尔兰有限公司版权所有。
Considerable evidence suggests that oxidative stress may be involved in the pathogenesis of Transmissible Spongiform Encephalopathies (TSEs). To investigate the involvement of iron metabolism in TSEs, we examined the expression levels of iron regulatory proteins (IRPs), ferritins, and binding activities of IRPs to iron-responsive element (IRE) in scrapie-infected mice. We found that the IRPs-IRE-binding activities and ferritins were increased in the astrocytes of hippocampus and cerebral cortex in the brains of scrapie-infected mice. These results suggest that alteration of iron metabolism contributes to development of neurodegeneration and that some protective mechanisms against iron-induced oxidative damage may occur during the pathogenesis of TSEs. (c) 2007 Elsevier Ireland Ltd. All rights reserved.