3D MR microscopy with resolution 3.7 μm by 3.3 μm by 3.3 μm
3D MR microscopy with resolution 3.7 μm by 3.3 μm by 3.3 μm
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DOI：
10.1016/s1090-7807(02)00071-x
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发表时间：
2002-09-01
影响因子：
2.2
通讯作者：
Pennington, CH
中科院分区：
文献类型：
--
作者：
Ciobanu, L;Seeber, DA;Pennington, CH
磁共振成像显微镜技术有望将核磁共振的全部功能带到空间不均匀系统（包括生物细胞）内的任意指定位置，但这种可能性受到对足够灵敏度和空间分辨率的需求的限制。我们报告了通过结合接收器线圈灵敏度、梯度强度和脉冲/梯度序列设计方面的进步而获得的质子磁共振图像。我们实现了 3.7 +/- 0.4 mum x 3.3 +/- 0.3 mum x 3.3 +/- 0.3 mum 的分辨率，体积分辨率类似于 40 飞升（相当于 3 x 10(12) 质子自旋）。 (C) 2002 年爱思唯尔科学（美国）。版权所有。
The technique of magnetic resonance imaging microscopy holds promise of bringing the full capabilities of NMR to arbitrarily specified positions within spatially inhomogeneous systems, including biological cells, yet the possibilities are limited by the need for adequate sensitivity and spatial resolution. We report proton magnetic resonance images obtained by combining advances in receiver coil sensitivity, gradient strength, and pulse/gradient sequence design. We achieve resolution of 3.7 +/- 0.4 mum by 3.3 +/- 0.3 mum by 3.3 +/- 0.3 mum for a volume resolution similar to40 femtoliters (corresponding to similar to3 x 10(12) proton spins). (C) 2002 Elsevier Science (USA). All rights reserved.