The progress and future of enhancing antiviral capacity by transgenic technology in the silkworm Bombyx mori
The progress and future of enhancing antiviral capacity by transgenic technology in the silkworm Bombyx mori
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家蚕转基因技术增强抗病毒能力的进展与展望
DOI：
10.1016/j.ibmb.2014.02.003
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发表时间：
2014-05-01
影响因子：
3.8
通讯作者：
Xia, Qingyou
中科院分区：
文献类型：
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作者：
Jiang, Liang;Xia, Qingyou
泥灰蝶是一种常见的鳞翅目模式昆虫，也是一种重要的丝绸生产经济昆虫。B。泥灰岩核型多角体病毒（marlnucleopolyhedrovirus，BmNPV）是一种典型的致病性杆状病毒，在蚕业生产中造成严重的经济损失。B。家蚕核型多角体病毒（BmNPV）和家蚕核型多角体病毒（BmNPV）是昆虫宿主和病原体相互作用的模型，包括病原体入侵宿主、宿主反应和增强宿主抗性。家蚕的抗病毒能力可以通过转基因技术来提高，例如内源性或外源性抗病毒基因的过表达、BmNPV基因的RNA干扰或调节免疫途径以在感染的不同阶段抑制BmNPV。通过结合不同的方法可以进一步提高抗病毒能力。我们讨论了家蚕抗病毒策略的未来，包括抗BmNPV的可能改进，构建对多种病毒具有抗性的转基因家蚕的可行性，以及转基因家蚕的安全性。该家蚕模型可为其他生物病害的防治提供参考。(C)2014作者由Elsevier Ltd.发布。这是一个CC BY-NC-ND许可下的开放获取文章
Bombyx marl is a common lepidopteran model and an important economic insect for silk production. B. marl nucleopolyhedrovirus (BmNPV) is a typical pathogenic baculovirus that causes serious economic losses in sericulture. B. mori and BmNPV are a model of insect host and pathogen interaction including invasion of the host by the pathogen, host response, and enhancement of host resistance. The antiviral capacity of silkworms can be improved by transgenic technology such as overexpression of an endogenous or exogenous antiviral gene, RNA interference of the BmNPV gene, or regulation of the immune pathway to inhibit BmNPV at different stages of infection. Antiviral capacity could be further increased by combining different methods. We discuss the future of an antiviral strategy in silkworm, including possible improvement of anti-BmNPV, the feasibility of constructing transgenic silkworms with resistance to multiple viruses, and the safety of transgenic silkworms. The silkworm model could provide a reference for disease control in other organisms. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license