Factors associated with excessive bleeding after cardiac surgery: A prospective cohort study
Factors associated with excessive bleeding after cardiac surgery: A prospective cohort study
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DOI：
10.1016/j.hrtlng.2015.09.003
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发表时间：
2016-01-01
期刊：
影响因子：
2.8
通讯作者：
Bottura Leite de Barros, Alba Lucia
中科院分区：
文献类型：
--
作者：
Lopes, Camila Takao;Reis Brunori, Evelise Fadini;Bottura Leite de Barros, Alba Lucia
目的：为了确定与心脏手术后出血过多（ExB）的adults.Background相关的因素：心脏手术后出血过多必须进行及时的interventions.Methods：一项前瞻性队列研究，323名需要开胸心脏手术的成人。通过单因素分析和Logistic回归分析与ExB相关的潜在因素。结果：ExB的影响因素包括性别、体重指数（BMI）、术前血小板计数、术中肝素用量和术中血小板输注。BMI的ROC曲线截止点为26.35;术前血小板计数为214，000，术中肝素剂量为6.25。结论：男性、BMI、术前血小板计数、术中肝素用量>312.5 mg且未输注血小板是ExB的相关因素。(C)2016 Elsevier Inc. All rights reserved.
Objective: To identify factors associated with excessive bleeding (ExB) after cardiac surgery in adults.Background: Excessive bleeding after cardiac surgery must be anticipated for implementation of timely interventions.Methods: A prospective cohort study with 323 adults requiring open-chest cardiac surgery. Potential factors associated with ExB were investigated through univariate analysis and logistic regression. The accuracy of the relationship between the independent variables and the outcome was depicted through the receiver-operating characteristic (ROC) curve.Results: The factors associated with ExB included gender, body mass index (BMI), preoperative platelet count, intraoperative heparin doses and intraoperative platelet transfusion. The ROC curve cut-off points were 26.35 for the BMI; 214,000 for the preoperative platelet count, and 6.25 for intraoperative heparin dose. This model had an accuracy = 77.3%, a sensitivity = 81%, and a specificity = 62%.Conclusions: Male gender, BMI, preoperative platelet count, dose of intraoperative heparin >312.5 mg without subsequent platelet transfusion, are factors associated with ExB. (C) 2016 Elsevier Inc. All rights reserved.