Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis
Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis
复制标题
DOI：
10.1111/j.1365-2133.2010.10185.x
复制
发表时间：
2011-04-11
影响因子：
10.3
通讯作者：
Kim, Y. -S.
中科院分区：
文献类型：
--
作者：
Lee, J. -H.;Choi, J. -W.;Kim, Y. -S.
背景关于BRAF和NRAS突变在原发性皮肤黑色素瘤中的患病率和临床病理学特征一直存在争议。在36项和31项研究中报告了BRAF和NRAS突变，分别涉及2521例和1972例患者。结果参数的影响大小计算的比值比（OR）。ResultsBRAF和NRAS基因突变报告在41%和18%的皮肤黑色素瘤，分别。这些突变与组织学亚型和肿瘤部位有关，但与年龄和性别无关。BRAF突变常在浅表扩散性黑色素瘤患者（OR = 2中心点021; P < 0中心点001）和发生于非慢性日光损伤皮肤的黑色素瘤患者（OR = 2中心点043; P = 0中心点001）中检测到。相比之下，NRAS突变在结节性黑色素瘤患者中频繁出现，（OR = 1中心点894; P < 0中心点001）和慢性日光损伤皮肤中出现的黑色素瘤（OR = 1中心点887; P = 0中心点018）结论该汇总分析显示，BRAF和NRAS突变在皮肤黑色素瘤中的发生率根据组织学类型而不同，肿瘤的位置根据阳光照射的程度。
P>BackgroundThere have been conflicting data regarding the prevalence and clinicopathological characteristics of BRAF and NRAS mutations in primary cutaneous melanoma.ObjectivesTo solve this controversy, this study used a meta-analysis to evaluate the frequencies of BRAF and NRAS mutations, and the relationship between these mutations and clinicopathological parameters of cutaneous melanoma.MethodsData from studies published between 1989 and 2010 were combined. The BRAF and NRAS mutations were reported in 36 and 31 studies involving 2521 and 1972 patients, respectively. The effect sizes of outcome parameters were calculated by odds ratios (OR).ResultsBRAF and NRAS mutations were reported in 41% and 18% of cutaneous melanomas, respectively. The mutations were associated with histological subtype and tumour site, but not with age and sex. The BRAF mutation was frequently detected in patients with superficial spreading melanoma (OR = 2 center dot 021; P < 0 center dot 001) and in melanomas arising in nonchronic sun-damaged skin (OR = 2 center dot 043; P = 0 center dot 001). In contrast, the NRAS mutation was frequently evident in patients with nodular melanoma (OR = 1 center dot 894; P < 0 center dot 001) and in melanomas arising in chronic sun-damaged skin (OR = 1 center dot 887; P = 0 center dot 018).ConclusionsThis pooled analysis shows that the incidences of BRAF and NRAS mutations in cutaneous melanomas differ according to histological type and tumour location based on the degree of sun exposure.