INCREASED FAT CONSUMPTION INDUCED BY MORPHINE ADMINISTRATION IN RATS
INCREASED FAT CONSUMPTION INDUCED BY MORPHINE ADMINISTRATION IN RATS
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DOI：
10.1016/0091-3057(82)90051-x
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
MARKSKAUFMAN, R
中科院分区：
文献类型：
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作者：
MARKSKAUFMAN, R
在雄性大鼠腹腔注射硫酸吗啡(0.0、1.0、10.0和20.0 mg/kg)后，观察了蛋白质、脂肪和碳水化合物3种常量营养素的热量摄入模式和膳食自我选择。动物被给予两种饮食自选方案中的一种，一种是高脂肪日粮(7.8千卡/克)，另一种是脂肪日粮与碳水化合物和蛋白质日粮等热量(3.8千卡/克)。动物在6小时喂食期开始时注射吗啡，并在注射后1、2、4和6小时测量营养摄入量。在高脂肪饮食的动物和注射吗啡后可以获得等卡路里成分的动物中，都观察到了类似的大量营养素选择模式。由于注射了吗啡，两种自选方案的动物都增加了脂肪摄入量，同时抑制了碳水化合物的摄入量，蛋白质摄入量几乎没有变化。
Patterns of caloric intakes and dietary self-selection of the 3 macronutrients, protein, fat and carbohydrate, were examined in male rats following the administration of morphine sulfate (0.0, 1.0, 10.0 and 20.0 mg/kg, i.p.). Animals were given access to either ground Purina Chow or 1 of 2 dietary self-selection regimes, one with a high-fat ration (7.8 kcal/g) and the other with a fat ration isocaloric to the carbohydrate and protein rations (3.8 kcal/g). Animals received morphine injections at the beginning of a 6-h feeding period and nutrient intakes were measured at 1, 2, 4 and 6 h postinjection. Similar patterns of macronutrient choice were observed for both animals maintained on the high-fat regime and animals with access to the isocaloric components following morphine injections. As a function of morphine injections, animals on both self-selection regimens increased fat intake while suppressing carbohydrate intake and exhibiting little modification in protein intake.