Inhibition-Induced Forgetting Results from Resource Competition between Response Inhibition and Memory Encoding Processes
Inhibition-Induced Forgetting Results from Resource Competition between Response Inhibition and Memory Encoding Processes
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DOI：
10.1523/jneurosci.0519-15.2015
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发表时间：
2015-08-26
影响因子：
5.3
通讯作者：
Egner, Tobias
中科院分区：
文献类型：
--
作者：
Chiu, Yu-Chin;Egner, Tobias
反应抑制是执行控制的一个重要组成部分，但它与其他认知过程的关系还不清楚。我们最近记录了“抑制诱导的遗忘效应”：不去的线索比去的线索记忆更差。我们将这种效应归因于中央资源竞争，即反应抑制从记忆编码中消耗注意力。然而，这一提议很难单独用行为手段来检验。因此，我们使用功能性磁共振成像在人类测试两个神经预测的“共同资源假说”：（1）大脑区域与反应抑制应表现出更大的资源需求，在编码随后被遗忘的比记住的不去的线索;（2）这种较高的抑制性资源需求应导致内存编码区域在编码随后被遗忘的不去的线索有较少的资源可用。参与者在一个去/不去的任务中按性别对面部刺激进行分类，并在延迟后对这些面部进行惊喜识别记忆测试。重复以前的研究结果，记忆更糟糕的是不去比去刺激。至关重要的是，高抑制性资源需求可以预测对禁止线索的遗忘，这可以通过神经“禁止”与“进行”网络中活动的逐个试验比率来量化。此外，这个抑制性需求指数与负责将不去提示编码到记忆中的大脑区域（特别是腹外侧前额叶皮层）的活动呈现出反向的逐次试验关系。反应抑制的神经资源需求和记忆编码相关活动之间的这种跷跷板模式直接支持了反应抑制暂时消耗注意资源的假设。
Response inhibition is a key component of executive control, but its relation to other cognitive processes is not well understood. We recently documented the "inhibition-induced forgetting effect": no-go cues are remembered more poorly than go cues. We attributed this effect to central-resource competition, whereby response inhibition saps attention away from memory encoding. However, this proposal is difficult to test with behavioral means alone. We therefore used fMRI in humans to test two neural predictions of the "common resource hypothesis": (1) brain regions associated with response inhibition should exhibit greater resource demands during encoding of subsequently forgotten than remembered no-go cues; and (2) this higher inhibitory resource demand should lead to memory encoding regions having less resources available during encoding of subsequently forgotten no-go cues. Participants categorized face stimuli by gender in a go/no-go task and, following a delay, performed a surprise recognition memory test for those faces. Replicating previous findings, memory was worse for no-go than for go stimuli. Crucially, forgetting of no-go cues was predicted by high inhibitory resource demand, as quantified by the trial-by-trial ratio of activity in neural "no-go" versus "go" networks. Moreover, this index of inhibitory demand exhibited an inverse trial-by-trial relationship with activity in brain regions responsible for the encoding of no-go cues into memory, notably the ventrolateral prefrontal cortex. This seesaw pattern between the neural resource demand of response inhibition and activity related to memory encoding directly supports the hypothesis that response inhibition temporarily saps attentional resources away from stimulus processing.