Role of tryptophan in carcinogenesis.
Role of tryptophan in carcinogenesis.
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色氨酸在致癌作用中的作用。
DOI：
10.1007/978-1-4613-1835-4_16
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发表时间：
1986
影响因子：
--
通讯作者：
Sidransky,H
中科院分区：
文献类型：
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作者：
Sidransky,H
本文回顾了一些早期关于色氨酸在增强选定化学致癌剂诱导的肿瘤发生中的作用的实验研究。多年来，色氨酸一直被认为与膀胱癌的发生有关。关于色氨酸对肝肿瘤发生的影响的证据是相互矛盾的。一些研究人员报告了增强作用，但其他研究人员报告了肿瘤发生的减少。回顾了色氨酸对肝脏的一些独特作用。此外，我们实验室的实验研究报告显示，当给大鼠喂食补充胆碱的饮食时，增加膳食色氨酸对诱导肝脏中 γ-谷氨酰转肽酶阳性病灶具有增强作用，但当给大鼠喂食缺乏胆碱的饮食 10 周时，没有发现增强作用。结果表明，通过在暴露于二乙基亚硝胺的大鼠肝脏中诱导γ-谷氨酰转肽酶阳性病灶来测量，增加膳食色氨酸对肝癌发生具有促进作用。回顾了这些发现的可能意义。
This paper reviews some of the earlier experimental studies concerning the role that tryptophan plays in enhancing tumorigenesis induced by selected chemical carcinogens. For many years, tryptophan has been implicated in carcinogenesis of the bladder. The evidence regarding tryptophan’s effect on hepatic tumorigenesis is conflicting; an enhancing effect has been reported by some investigators, but a reduction in tumorigenesis has been reported by other workers. Some of the unique effects that tryptophan exerts upon the liver are reviewed. Also, experimental studies from our laboratory are reported in which we observed a potentiating effect of increased dietary tryptophan on the induction of γ-glutamyltranspeptidase-positive foci in liver when rats were fed a choline-supplemented diet but no potentiation was found when rats were fed a choline-deficient diet for 10 weeks. The results suggest that increased dietary tryptophan has a promoting effect on liver carcinogenesis as measured by the induction of γ-glutamyltranspeptidase-positive foci in the livers of rats exposed to diethylnitrosamine. The possible significance of these findings is reviewed.