Pattern and timing of gene duplication in animal genomes
Pattern and timing of gene duplication in animal genomes
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DOI：
10.1101/gr.200601
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发表时间：
2001-11-01
期刊：
影响因子：
7
通讯作者：
Hughes, AL
中科院分区：
文献类型：
--
作者：
Friedman, R;Hughes, AL
基因的复制，产生了多。基因家族的基因组是真核生物基因组进化的一个特征。在脊椎动物的情况下，已经提出基因数量的增加是由于整个基因组通过多倍化进行两轮复制（2 R假说）。在迄今为止最广泛的测试这一假设，我们比较了同源家族的基因数量，并进行了系统发育分析的基因家族与2至8个成员的完整基因组的秀丽隐杆线虫和果蝇和人类基因组的可用部分。虽然人类基因组显示出比其他动物基因组更高的比例最近的基因重复，重复后口-原口分裂后的比例是恒定的家庭，没有这样的重复在四个成员的家庭，相反的预期2 R假说。绝大多数（70.9%）的人类四成员家庭和四成员集群在较大的家庭表现出拓扑结构不一致的两轮在脊椎动物的多倍化。
Duplication of genes, giving rise to multi.-ene families, has been a characteristic feature of the evolution of eukaryotic genomes. In the case of vertebrates, it has been proposed that an increase in gene number resulted from two rounds of duplication of the entire genome by polyploidization (the 2R hypothesis). In the most extensive test to date of this hypothesis, we compared gene numbers in homologous families and conducted phylogenetic analyses of gene families with two to eight members in the complete genomes of Caenorhabditis elegans and Drosophila melanogaster and the available portion of the human genome. Although the human genome showed a higher proportion of recent gene duplications than the other animal genomes, the proportion of duplications after the deuterostome-protostome split was constant across families, with no peak of such duplications in four-member families, contrary to the expectation of the 2R hypothesis. A substantial majority (70.9%) of human four-member families and four-member clusters in larger families showed topologies inconsistent with two rounds of polyploidization in vertebrates.