NIMH clinical research branch collaborative program on the psychobiology of depression.
NIMH clinical research branch collaborative program on the psychobiology of depression.
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NIMH 抑郁症心理生物学临床研究分支合作项目。
DOI：
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发表时间：
1979
影响因子：
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通讯作者：
S. Koslow
中科院分区：
文献类型：
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作者：
M. Katz;S. Secunda;R. Hirschfeld;S. Koslow
这是一份关于合作努力的历史和影响的报告，从1969年国家心理健康研究所关于抑郁症的心理生物学会议演变而来。当时确定的主要问题是需要(1)评估当前病分学系统的相对有效性和(2)重新测试有关抑郁症的病因和性质的关键生物学假设。需要进行多学科的研究，并涉及治疗不同类型抑郁症的临床环境。描述了旨在解决这些问题的生物和临床合作项目的目标和性质。这些独特的项目始于20世纪70年代初，目前涵盖了病分学、遗传学、神经化学、神经内分泌学和社会心理因素的研究。尽管这些研究仍处于早期阶段，但它们已经在诊断、描述性精神病理学和生物学测量方面取得了重大的方法学进展。
This is a report on the history and implications of the collaborative effort that evolved from the 1969 National Institute of Mental Health conference on the psychobiology of depression. The major issues identified at that time were the need to (1) assess relative validities of current systems of nosology and (2) retest critical biological hypotheses concerning the etiology and nature of the depressive disorders. Research was required that would be multidisciplinary and involve clinical settings treating diverse types of depression. The objectives and the nature of the biological and clinical collaborative programs that were designed to address these problems are described. These unique programs, initiated in the early 1970s, currently span research on nosology, genetics, neurochemistry, neuroendocrinology, and psychosocial factors. Although these studies are still in the early stages, they have resulted in significant methodologic developments in diagnosis, descriptive psychopathology, and biological measurements.