Active Surveillance in Prostate Cancer: Role of Available Biomarkers in Daily Practice.
Active Surveillance in Prostate Cancer: Role of Available Biomarkers in Daily Practice.
复制标题
DOI：
10.3390/ijms22126266
复制
发表时间：
2021-06-10
影响因子：
5.6
通讯作者：
López-Guerrero JA
中科院分区：
文献类型：
--
作者：
Pastor-Navarro B;Rubio-Briones J;Borque-Fernando Á;Esteban LM;Dominguez-Escrig JL;López-Guerrero JA
前列腺癌（PCa）是男性中最常见的癌症。目前的诊断是基于PSA水平，这与过度诊断和过度治疗有关。此外，大多数PCa是局部肿瘤;因此，许多低/极低风险PCa患者可以从主动监测（AS）计划中获益，而不是更积极的积极治疗。纳入标准和随访策略的异质性是AS目前面临的主要争议问题。许多生物标志物目前正在研究中，然而，还没有表现出足够的诊断能力作为一个独立的预测病理或临床进展。这项工作的目的是审查目前可用的文献组织，血液和尿液生物标志物在临床实践中验证的AS患者的管理。
Prostate cancer (PCa) is the most commonly diagnosed cancer in men. The diagnosis is currently based on PSA levels, which are associated with overdiagnosis and overtreatment. Moreover, most PCas are localized tumours; hence, many patients with low-/very low-risk PCa could benefit from active surveillance (AS) programs instead of more aggressive, active treatments. Heterogeneity within inclusion criteria and follow-up strategies are the main controversial issues that AS presently faces. Many biomarkers are currently under investigation in this setting; however, none has yet demonstrated enough diagnostic ability as an independent predictor of pathological or clinical progression. This work aims to review the currently available literature on tissue, blood and urine biomarkers validated in clinical practice for the management of AS patients.
登录
查看更多内容
影响因子：
64.5
作者：
Cancer Genome Atlas Research Network
通讯作者：
Cancer Genome Atlas Research Network
影响因子：
6.6
作者：
BENSON, MC;WHANG, IS;COONER, WH
通讯作者：
COONER, WH
影响因子：
3.7
作者：
Chiu, Peter Ka-Fung;Lai, Fernand Mac-Moune;Ng, Chi-Fai
通讯作者：
Ng, Chi-Fai
DOI：
10.1016/j.urolonc.2014.12.002
发表时间：
2015-04-01
影响因子：
2.7
作者：
Cantiello, Francesco;Russo, Giorgio Ivan;Damiano, Rocco
通讯作者：
Damiano, Rocco
影响因子：
23.4
作者：
Canter, Daniel J.;Reid, Julia;Bardot, Stephen
通讯作者：
Bardot, Stephen