CYTOMEGALO-VIRUS RETINITIS AND ACQUIRED IMMUNODEFICIENCY SYNDROME
CYTOMEGALO-VIRUS RETINITIS AND ACQUIRED IMMUNODEFICIENCY SYNDROME
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DOI：
10.1001/archopht.1989.01070010077031
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发表时间：
1989-01-01
影响因子：
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通讯作者：
BARTLETT, JG
中科院分区：
文献类型：
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作者：
JABS, DA;ENGER, C;BARTLETT, JG
在157例获得性免疫缺陷综合征（AIDS）患者中，46例（29%）发生了巨细胞病毒（CMV）视网膜炎。在5名患者中，CMV视网膜炎是最初的AIDS定义的机会性感染（11%的CMV视网膜炎患者和3%的AIDS患者）。7例患者（15%）发生视网膜脱离，4例患者在更昔洛韦治疗前出现视网膜脱离。35%的患者出现双侧CMV视网膜炎，随后15例患者中有9例（60%）未接受更昔洛韦治疗。相反，18例单侧疾病患者在接受更昔洛韦治疗时均未发生双侧疾病。在接受更昔洛韦治疗CMV视网膜炎的患者中，81%对药物有反应，61%达到完全反应，导致非进展性和非活动性瘢痕。更昔洛韦完全应答的患者生存期明显长于未完全应答的患者，这表明更昔洛韦无效的患者免疫功能受损更严重。
In a series of 157 patients with acquired immunodeficiency syndrome (AIDS), 46 (29%) developed cytomegalovirus (CMV) retinitis. In five patients, CMV retinitis was the initial AIDS-defining opportunistic infection (11% of patients with CMV retinitis and 3% of patients with AIDS). Retinal detachments developed in seven patients (15%) and in four were present before the institution of ganciclovir therapy. Bilateral CMV retinitis was present in 35% of patients at presentation and subsequently developed in nine (60%) of 15 patients while not being treated with ganciclovir. Conversely, none of 18 patients with unilateral disease developed bilateral disease while receiving ganciclovir. Of patients treated with ganciclovir for their CMV retinitis, 81% had a response to the drug, and 61% achieved a complete response, resulting in a nonprogressive and inactive scar. Patients who achieved a complete response with ganciclovir had a significantly longer survival than those who did not, suggesting greater immune compromise in those patients who failed to respond to ganciclovir.