Aspirin alleviates skin inflammation and angiogenesis in rosacea
Aspirin alleviates skin inflammation and angiogenesis in rosacea
复制标题
阿司匹林可减轻红斑痤疮的皮肤炎症和血管生成。
DOI：
10.1016/j.intimp.2021.107558
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发表时间：
2021-03-17
影响因子：
5.6
通讯作者：
Li, Ji
中科院分区：
文献类型：
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作者：
Deng, Zhili;Xu, San;Li, Ji
酒渣鼻是一种慢性、复发性炎症性皮肤病，其特征是免疫反应的异常激活、血管功能障碍和显著的渗透屏障改变。阿司匹林作为第一种非甾体类抗炎药（NSAID），由于其抗炎和抗血管生成的特性而被广泛用于各种炎症性疾病。然而，其对红斑痤疮的影响尚不清楚。在这项研究中，我们证明了阿司匹林显着改善LL 37诱导的玫瑰痤疮样小鼠的病理表型。RNA测序分析显示阿司匹林主要通过调节免疫反应减轻玫瑰痤疮样皮肤皮炎。从机制上讲，我们发现阿司匹林减少了与酒渣鼻相关的趋化因子和细胞因子的产生，并抑制了LL 37诱导的酒渣鼻样小鼠的Th 1和Th 17极化免疫应答。此外，阿司匹林还能降低玫瑰痤疮样皮肤的微血管密度和VEGF表达。我们进一步证明阿司匹林抑制NF-κ B信号的激活及其下游促炎细胞因子的释放。总之，我们发现阿司匹林通过减弱皮肤炎症和血管生成对酒渣鼻发挥疗效，这表明它是治疗酒渣鼻的一种有前景的治疗候选药物。
Rosacea is a chronic, relapsing inflammatory skin disease featured by abnormal activation of immune responses, vascular dysfunction and prominent permeability barrier alterations. Aspirin, as the first nonsteroidal antiinflammatory drug (NSAID), is widely used for various inflammatory conditions due to its anti-inflammatory and anti-angiogenic properties. However, its effects on rosacea are unclear. In this study, we demonstrated that aspirin dramatically improved pathological phenotypes in LL37-induced rosacea-like mice. The RNA sequencing analysis revealed that aspirin alleviated rosacea-like skin dermatitis mainly via modulating immune responses. Mechanically, we showed that aspirin decreased the production of chemokines and cytokines associated with rosacea, and suppressed the Th1-and Th17-polarized immune responses in LL37-induced rosacea-like mice. Besides, aspirin administration decreased the microvessels density and the VEGF expression in rosacea-like skin. We further demonstrated that aspirin inhibited the activation of NF-KB signaling and the release of its downstream pro-inflammatory cytokines. Collectively we showed that aspirin exerts a curative effect on rosacea by attenuating skin inflammation and angiogenesis, suggesting a promising therapeutic candidate for the treatment of rosacea.