Quality of life after treatment for localized prostate cancer: Differences based on treatment modality
Quality of life after treatment for localized prostate cancer: Differences based on treatment modality
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DOI：
10.1016/s0022-5347(05)65870-3
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发表时间：
2001-09-01
影响因子：
6.6
通讯作者：
Schellhammer, PF
中科院分区：
文献类型：
--
作者：
Davis, JW;Kuban, DA;Schellhammer, PF
目的：(103)钯 ((103) Pd) 近距离放射治疗是一种越来越多的局部前列腺癌治疗方式。我们比较了同一时间段内进行 Pd-103 治疗、根治性前列腺切除术和外照射放射治疗后的一般和疾病特定健康相关生活质量。材料和方法：我们对 1995 年至 1999 年间在单个社区医疗中心接受治疗的患者进行了一项回顾性横断面调查研究。我们向 269 名、142 名和 222 名接受根治性前列腺切除术的男性邮寄了 5 份经过验证的健康相关生活质量调查工具， Pd-103 治疗和外照射放射治疗各组的有效率均大于 80%。 结果：SF-36 评估的一般健康相关生活质量在接受前列腺切除术和 Pd-103 治疗的患者中得分相同。加州大学洛杉矶分校前列腺癌指数用于评估肠道、泌尿和性功能/烦恼。据报道，外照射放射治疗与肠道功能恶化和肠道不适有关。与 Pd-103 和外照射放射治疗相比，前列腺切除术与更差的泌尿功能相关。与 Pd-103 或外照射放射治疗相比，前列腺切除术与性功能较差相关，尽管神经保留手术和勃起辅助器使这种差异最小化。美国泌尿外科协会 Pd-103 的症状评分最初较高，但在调查后治疗超过 12 个月的患者中，与其他组的症状评分相同。接受前列腺切除术和 Pd-103 近距离放射治疗的无病男性同样相信癌症将来不会复发。所有组的满意度相同，生化失败显着降低了满意度。结论：虽然与一般健康相关的生活质量大多不受前列腺癌 3 种最常见治疗方法的影响，但肠道、泌尿和性功能存在差异。这些信息可以帮助患者做出决策。
Purpose: Brachytherapy with (103)palladium ((103) Pd) is an increasingly administered treatment modality for localized prostate cancer. We compared general and disease specific health related quality of life after Pd-103 treatment, radical prostatectomy and external beam radiation therapy given during the same time frame.Materials and Methods: We performed a retrospective cross-sectional survey study of patients treated at a single community medical center between 1995 and 1999. We mailed 5 validated health related quality of life survey instruments to 269, 142 and 222 men who underwent radical prostatectomy, Pd-103 treatment and external beam radiation therapy, respectively, with a response rate of greater than 80% in all groups.Results: General health related quality of life assessed by the SF-36 showed the same scores in patients who underwent prostatectomy and Pd-103 treatment. The University of California-Los Angeles Prostate Cancer Index was used to assess bowel, urinary and sexual function/bothersomeness. External beam radiation therapy reported was associated with worse bowel function and greater bowel bothersomeness. Prostatectomy was associated with worse urinary function compared to Pd-103 and external beam radiation therapy. Prostatectomy was associated with worse sexual function than Pd-103 or external beam radiation therapy, although nerve sparing surgery and erectile aids minimized the difference. American Urological Association symptom scores were initially higher for Pd-103 but became equal to those in the other groups in patients treated greater than 12 months from survey time. Disease-free men who underwent prostatectomy and Pd-103 brachytherapy were equally confident that cancer would not recur in the future. Satisfaction rates were equivalent and biochemical failure significantly decreased satisfaction in all groups.Conclusions: While general health related quality of life was mostly unaffected by the 3 most common treatments for prostate cancer, there were differences in bowel, urinary and sexual function. This information may aid patients in the decision making process.