Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease
Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease
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DOI：
10.1007/s00228-008-0532-4
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发表时间：
2008-09-01
影响因子：
2.9
通讯作者：
Jordan, Jens
中科院分区：
文献类型：
--
作者：
Adams, Frauke;Boschmann, Michael;Jordan, Jens
目的帕金森病患者的体重明显减轻可能与左旋多巴治疗对脂肪动员/氧化的直接影响有关。我们评估了全身和局部代谢反应左旋多巴/苄丝肼在特发性Parkinson's diseases.Methods患者，我们研究了10帕金森病患者和检查脂肪组织和骨骼肌代谢直接与微透析。我们监测透析液中乙醇、葡萄糖、乳酸盐、丙酮酸盐和甘油的浓度，以评估左旋多巴/苄丝肼摄入前后的组织血流和代谢。结果左旋多巴/苄丝肼可使血清左旋多巴、3，4-二羟基苯乙酸（DOPAC）和去甲肾上腺素水平升高（P < 0.01）。血清脂肪组织和骨骼肌甘油没有变化或降低。脂肪组织甘油含量与血清左旋多巴浓度呈负相关（P < 0.05）。结论左旋多巴/苄丝肼可明显改变脂肪组织和骨骼肌的代谢，使脂肪代谢由脂质向糖代谢转变。在脂肪组织中，左旋多巴/苄丝肼未能激活脂解。因此，我们认为左旋多巴/苄丝肼不会通过对脂肪组织代谢的直接和急性影响来诱导脂肪消耗。
Objective The substantial weight loss in Parkinson's patients may be related to direct influences of levodopa treatment on fat mobilization/oxidation. We assessed systemic and local metabolic responses to levodopa/benserazide in patients with idiopathic Parkinson's disease.Methods We studied 10 Parkinson's disease patients and examined adipose tissue and skeletal muscle metabolism directly with microdialysis. We monitored dialysate concentrations of ethanol, glucose, lactate, pyruvate, and glycerol to assess tissue blood flow and metabolism before and after levodopa/benserazide intake. We also conducted in vitro studies on adipocytes from healthy women.Results Levodopa/benserazide increased serum levodopa, 3,4-dihydroxyphenylacetic acid (DOPAC), and norepinephrine (P < 0.01). Serum adipose tissue and skeletal muscle glycerol did not change or decreased. Adipose tissue glycerol was inversely correlated with serum levodopa concentrations (P < 0.05). In isolated adipocytes, levodopa attenuated isoproterenol-induced glycerol release (P < 0.05).Conclusion Levodopa/benserazide elicits pronounced metabolic changes in both adipose tissue and skeletal muscle with a switch from lipid to carbohydrate metabolism. In adipose tissue, levodopa/benserazide failed to activate lipolysis. Therefore, we suggest that levodopa/benserazide does not induce fat wasting through direct and acute influences on adipose tissue metabolism.