Prenatal exposure to famine and brain morphology in schizophrenia
Prenatal exposure to famine and brain morphology in schizophrenia
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DOI：
10.1176/appi.ajp.157.7.1170
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发表时间：
2000-07-01
影响因子：
17.7
通讯作者：
Kahn, RS
中科院分区：
文献类型：
--
作者：
Hulshoff, HE;Hoek, HW;Kahn, RS
目的：作者评估了妊娠早期营养缺乏对精神分裂症患者大脑形态的影响。方法：通过磁共振脑成像对妊娠早期暴露于荷兰饥饿冬季的 9 名精神分裂症患者和 9 名健康对照受试者以及产前未接触过荷兰饥饿冬季的 9 名精神分裂症患者和 9 名健康受试者进行评估。 结果：精神分裂症患者产前经历饥荒与颅内容量减少相关。产前饥饿冬季暴露与大脑异常（主要是白质高信号）的增加有关。结论：妊娠前三个月的营养缺乏导致临床大脑异常的增加，并与精神分裂症患者早期大脑发育异常有关。因此，妊娠前三个月影响大脑生长的因素继发的大脑发育迟缓可能是患精神分裂症的潜在危险因素。
Objective: The authors assessed the effects of nutritional deficiency during the first trimester of pregnancy on brain morphology in patients with schizophrenia.Method: Nine schizophrenic patients and nine healthy comparison subjects exposed during the first trimester of gestation to the Dutch Hunger Winter were evaluated with magnetic resonance brain imaging, as were nine schizophrenic patients and nine healthy subjects who were not prenatally exposed to the famine.Results: Prenatal famine exposure in patients with schizophrenia was associated with decreased intracranial volume. Prenatal Hunger Winter exposure alone was related to an increase in brain abnormalities, predominantly white matter hyperintensities.Conclusions: Nutritional deficiency during the first trimester of gestation resulted in an increase in clinical brain abnormalities and was associated with aberrant early brain development in patients with schizophrenia. Stunted brain development secondary to factors that affect brain growth during the first trimester of gestation may thus be a potential risk factor for developing schizophrenia.