Thymus-independent expansion of T lymphocytes in children after allogeneic bone marrow transplantation
Thymus-independent expansion of T lymphocytes in children after allogeneic bone marrow transplantation
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DOI：
10.1038/sj.bmt.1702198
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发表时间：
2000-03
影响因子：
4.8
通讯作者：
K. Honda;H. Takada;Y. Nagatoshi;K. Akazawa;S. Ohga;E. Ishii;J. Okamura;T. Hara
中科院分区：
文献类型：
--
作者：
K. Honda;H. Takada;Y. Nagatoshi;K. Akazawa;S. Ohga;E. Ishii;J. Okamura;T. Hara
胸腺依赖性途径和胸腺非依赖性途径在儿童骨髓移植后T细胞再生中的作用尚不清楚。我们分析了同种异体骨髓移植后T细胞再生途径的动力学。CD 4 + CD 45 RA + T细胞的数量，胸腺依赖性群体，是非常低的，直到3个月后BMT。CD 28 − T细胞和表达CD 8 α/α同源二聚体的CD 8 + T细胞（CD 8 α/α+ T细胞）的数量在BMT后不久增加，超过了一些患者健康儿童的水平。骨髓移植后6个月，胸腺外发育的Vγ9+、Vδ2+和Vα24+ T细胞数量均低于200个/μl。在BMT后1个月，CD 4 + CD 45 RA+和CD 28-T细胞百分比之间呈显著负相关，而在BMT后2和3个月，CD 28 −和CD 8 α/α+ T细胞百分比之间呈正相关。CD 8 α/α+ T细胞水平高的患者进行BMT时的平均年龄高于这些细胞水平没有增加的患者，这表明胸腺功能对再生途径的影响。这些结果表明，胸腺非依赖性途径是T细胞的主要来源，即使在儿童后不久同种异体BMT。骨髓移植（2000）25，647-652。
The contribution of the thymus-dependent pathway and thymus-independent pathways for T cell regeneration after BMT in children is still unclear. We analyzed the kinetics of T cell regenerative pathways after allogeneic BMT. The number of CD4+ CD45RA+ T cells, a thymus-dependent population, was very low until 3 months after BMT. The numbers of CD28− T cells and CD8+ T cells expressing CD8α/α homodimer (CD8α/α+ T cells), a thymus-independent population, increased shortly after BMT, beyond the levels of healthy children in some patients. The numbers of Vγ9+ Vδ2+ and Vα24+ T cells, which represent populations of extrathymic development, were less than 200/μl during the 6 months after BMT. There was a significant inverse correlation between the percentages of CD4+ CD45RA+ and CD28-T cells at 1 month, and a positive correlation between the percentages of CD28− and CD8α/α+ T cells at 2 and 3 months after BMT. The mean age at BMT was higher in patients with a high level of CD8α/α+ T cells than in those without an increase in these cells, suggesting the influence of thymic function on the regenerative pathways. These results suggest that the thymus-independent pathway is the dominant source of T cells even in children shortly after allogeneic BMT. Bone Marrow Transplantation (2000) 25, 647–652.