Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold
Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold
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DOI：
10.1016/j.bmc.2008.05.081
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发表时间：
2008-07-15
影响因子：
3.5
通讯作者：
Xu, Wen Fang
中科院分区：
文献类型：
--
作者：
Tu, GuoGang;Li, ShaoHua;Xu, Wen Fang
The aminopeptidase N (APN/CD13), overexpressed in tumor cells, plays a critical role in angiogenesis. In this study, we report the synthesis and in vitro enzyme inhibition assay of 1,3,4-thiadiazole scaffold compounds. These new compounds have potent inhibitory activities toward APN with IC50 values in the micromol rang. (c) 2008 Elsevier Ltd. All rights reserved.
